Differential laminar distribution of tyrosine hydroxylase-immunoreactive axons in infant and adult monkey prefrontal cortex.
Differential laminar distribution of tyrosine hydroxylase-immunoreactive axons in infant and adult monkey prefrontal cortex.
复制标题
婴儿和成年猴前额皮质酪氨酸羟化酶免疫反应性轴突的差异层状分布。
DOI：
10.1016/0304-3940(91)90014-k
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发表时间：
1991
影响因子：
2.5
通讯作者：
Harris,HW
中科院分区：
文献类型：
--
作者：
Lewis,DA;Harris,HW
用免疫组织化学方法观察了幼年和成年恒河猴前额叶皮质第9区酪氨酸羟化酶(TH)免疫反应阳性轴突的层状分布。在新生动物中，TH阳性轴突位于皮质浅层和深层，而在成年动物中，标记纤维更均匀地分布在所有层中。这些差异反映了新生儿大脑皮质浅层纤维密度比成人高35%以上，而皮质中层纤维密度比新生儿高100%以上。纤维分布的最显著变化似乎发生在生命的最初几个月。这些发现可能揭示了多巴胺在调节新生猴子和成年猴子前额叶皮质功能方面的不同作用。
Immunohistochemical techniques were used to evaluate the laminar distribution of tyrosine hydroxylase (TH)-immunoreactive axons in area 9 of infant and adult rhesus monkey prefrontal cortex. In neonatal animals, TH-positive axons had a bilaminar location in the superficial and deep cortical layers, whereas in the adults, labeled fibers were more evenly distributed across all layers. These differences reflected the fact that fiber density in the superficial layers was over 35% greater in neonates than in adults, but in the middle cortical layers, fiber density was over 100% greater in adults than in neonates. The most striking changes in fiber distribution appeared to occur during the first few months of life. These findings may reveal differences in the role of dopamine in the regulation of prefrontal cortical function in neonatal and adult monkeys.