Elevated levels of IL-24 in systemic lupus erythematosus patients
Elevated levels of IL-24 in systemic lupus erythematosus patients
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DOI：
10.1177/0961203319845476
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发表时间：
2019-05-01
期刊：
影响因子：
2.6
通讯作者：
Huang, A. F.
中科院分区：
文献类型：
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作者：
Li, R. C.;Guo, J.;Huang, A. F.
目的探讨系统性红斑狼疮（SLE）患者血清IL-24水平及其与临床表现的关系。采用酶联免疫吸附试验测定血清IL-24水平，采用实时定量聚合酶链反应检测IL-24 mRNA水平。结果SLE患者血清IL-24水平显著高于健康对照组，而SLE患者血清IL-24水平显著高于健康对照组，差异有统计学意义（P < 0. 05）。SLE伴肾炎组IL-24水平高于无肾炎组。活动性SLE患者与活动性较低的疾病患者相比，IL-24的表达更高。SLE患者IL-24 mRNA水平明显升高。相关分析显示血清IL-24水平与SLE疾病活动指数显著相关。结论炎性细胞因子与SLE疾病活动性相关，可能参与了SLE的发病机制。
Objective This study aimed to assess IL-24 levels and their association with clinical manifestations in patients with systemic lupus erythematosus (SLE).Methods There were 75 patients with SLE and 58 healthy controls recruited in this study. Serum levels of IL-24 were measured by enzyme-linked immunosorbent assays, and mRNA levels of IL-24 were tested by quantitative real-time polymerase chain reaction. The area under the curve of the receiver operating characteristic (ROC) curve was used for diagnostic ability of the inflammatory cytokine.Results Serum IL-24 levels were significantly higher in SLE patients than that in healthy controls. SLE patients with nephritis had higher IL-24 levels than those without nephritis. Active SLE patients showed higher expression of IL-24 as compared to less active disease patients. The mRNA levels of IL-24 were much higher in SLE patients. Correlation analysis showed significant correlation between serum IL-24 levels and SLE disease activity index. In addition, ROC analysis may suggest good ability of serum IL-24 in differentiating SLE.Conclusion The inflammatory cytokine correlated with SLE disease activity, and may be involved in this disease pathogenesis.