PNE Versus 1st Stage Tined Lead Procedure: A Direct Comparison to Select the Most Sensitive Test Method to Identify Patients Suitable for Sacral Neuromodulation Therapy
PNE Versus 1st Stage Tined Lead Procedure: A Direct Comparison to Select the Most Sensitive Test Method to Identify Patients Suitable for Sacral Neuromodulation Therapy
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DOI：
10.1002/nau.20979
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发表时间：
2011-01-01
影响因子：
2
通讯作者：
van Kerrebroeck, Philip E. V.
中科院分区：
文献类型：
--
作者：
Leong, Randall K.;De Wachter, Stefan G. G.;van Kerrebroeck, Philip E. V.
目的：比较经皮神经功能评价试验(PNE)和第一阶段TING-LINE定位试验(FSTLP)对经皮神经调节治疗(SNM)患者的疗效。方法：对难治性特发性膀胱过度活动症(OAB)或非梗阻性尿潴留患者进行单中心研究，同时进行PNE和FSTLP筛查。对患者进行前瞻性随访，比较两组患者PNE与FSTLP后膀胱日记的缓解率。至少两种相关的尿路症状改善超过50%被认为是阳性反应。用Wilcoxon配对检验来比较两种筛查选项的比率和Logistic回归以确定可能的相关性。进行了随访，以确定长期失败率。结果：共纳入100例患者，其中女性82例，OAB 69例。平均年龄55岁(SD 13)。PNE阳性反应率为47%。FSTLP阳性反应率为69%，与年龄呈负相关。阳性反应增加22%具有统计学意义(P<；0.001)，并且与女性和年轻年龄呈正相关。69例FSTLP阳性的患者均接受了SNM治疗。平均2年失败率为2.9%。结论：这项研究表明，FSTLP可能是一种比PNE更敏感的筛查方法，以确定符合SNM治疗条件的患者，值得进行随机试验。诺鲁罗。乌罗戴恩。2011年12月30日1249-1252。(C)2011年Wiley-Liss，Inc.
Aims: To compare the patient's response rate to the Percutaneous Nerve Evaluation test (PNE) and the 1st stage tined-lead placement test (FSTLP) for sacral neuromodulation therapy (SNM). Methods: Single center study on patients with refractory idiopathic overactive bladder syndrome (OAB) or non-obstructive urinary retention, screened with both PNE and FSTLP. Patients were followed prospectively and their response rate based on bladder diary after PNE was compared to that after FSTLP. More than 50% improvement in at least two relevant urinary symptoms was considered a positive response. A Wilcoxon paired test was done to compare the rates of the two screening options and logistic regression to determine possible associations. A follow-up was conducted to determine the long-term failure rate. Results: One hundred patients were included (82 female, 69 OAB). The mean age was 55 years (SD 13). The positive response rate on PNE was 47%. FSTLP showed a 69% positive response rate, which was negatively related to age. The 22% gain in positive response was statistically significant (P < 0.001) and positively associated with female gender and younger age. All 69 patients with a positive response to FSTLP received SNM treatment. Failure rate after an average of 2 years was 2.9%. Conclusions: This study suggests that FSTLP may be a more sensitive screening method than PNE to identify patients eligible for SNM therapy, warranting randomized trials. Neurourol. Urodyn. 30:1249-1252, 2011. (C) 2011 Wiley-Liss, Inc.