Localization of amyloid P component in human brain: vascular staining patterns and association with Alzheimer's disease lesions.
Localization of amyloid P component in human brain: vascular staining patterns and association with Alzheimer's disease lesions.
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淀粉样蛋白 P 成分在人脑中的定位：血管染色模式及其与阿尔茨海默病病变的关联。
DOI：
10.1002/cne.903520107
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Chui,HC
中科院分区：
文献类型：
--
作者：
Perlmutter,LS;Barron,E;Myers,M;Saperia,D;Chui,HC
淀粉样蛋白P成分是一种正常的血清蛋白，在整个系统发育中高度保守。虽然它类似于经典的急性期反应物C反应蛋白，并且被认为是正常的细胞外基质成分，但其在人体中的生理作用尚不清楚。淀粉样蛋白P成分也与所有已知形式的淀粉样蛋白聚集在一起。本研究使用光镜和电镜比较了阿尔茨海默病（AD）患者（n = 19）和非阿尔茨海默病（AD）患者（n = 15）淀粉样蛋白P成分的大脑定位。在非AD病例中，淀粉样蛋白P成分主要局限于脑血管。在大多数病例中观察到血管周围染色，白质比灰质更明显。在AD病例中，淀粉样蛋白P成分局限于所有三种特征性组织病理病变，即神经原纤维缠结、老年斑和淀粉样血管病。此外，在灰质实质病变染色突出的病例中，血管内染色减少。鉴于所采用的固定和加工方法，淀粉样蛋白P组分从未被发现定位于脑血管基底膜。这些数据反驳了淀粉样蛋白P组分作为血管β -淀粉样蛋白沉积锚点的假设作用。由于没有证据表明脑内产生固有的淀粉样蛋白P成分，其血管周围和实质分布表明血脑屏障受损或通过血管内皮运输。©1995 Wiley‐Liss, Inc。
Amyloid P component is a normal serum protein that is highly conserved across phylogeny. Although it resembles the classic acute‐phase reactant C‐reactive protein, and is considered to be a normal extracellular matrix component, its physiologic role in humans is unknown. Amyloid P component is also colocalized with accumulations of all recognized forms of amyloid. The present study uses light and electron microscopy to compare the cerebral localization of amyloid P component in cases with (n = 19) and without (n = 15) Alzheimer's disease (AD). In non‐AD cases, amyloid P component was predominantly localized to the cerebrovasculature. Perivascular staining was observed in most cases, more so in the white than in the gray matter. In AD cases, amyloid P component was localized to all three characteristic histopathologic lesions, namely, neurofibrillary tangles, senile plaques, and amyloid angiopathy. Furthermore, in cases with prominent staining of gray matter parenchymal lesions, intravascular staining was decreased. Given the fixation and processing methods used, amyloid P component was never seen to be localized to the cerebrovascular basement membrane. These data argue against amyloid P component's postulated role as the anchor for vascular β‐amyloid deposition. Because there is no evidence for intrinsic amyloid P component production in brain, its perivascular and parenchymal distributions suggest either compromise of the blood‐brain barrier or transport across vascular endothelium. © 1995 Wiley‐Liss, Inc.