Virus-induced demyelination in nude mice is mediated by γδ T cells
Virus-induced demyelination in nude mice is mediated by γδ T cells
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DOI：
10.1016/s0002-9440(10)64402-1
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发表时间：
2002-10-01
影响因子：
6
通讯作者：
Perlman, S
中科院分区：
文献类型：
--
作者：
Dandekar, AA;Perlman, S
用小鼠肝炎病毒（MHV）JHM株感染小鼠，导致急性和慢性脱髓鞘，与人类多发性硬化症有许多相似之处。这种病理过程主要是T细胞介导的，缺乏B和T细胞的小鼠的MHV感染不会导致脱髓鞘。与这些结果明显矛盾的是，在MHV感染的年轻裸（无胸腺）小鼠中检测到稳健的脱髓鞘。在此，我们表明，脱髓鞘在裸鼠介导的γ δ T细胞。这些细胞，但不是传统的CD4或CD8 α T细胞，检测到在中枢神经系统的MHV感染的裸鼠和他们的消耗与中和抗体导致脱髓鞘减少80%。这些结果首次表明，γ δ T细胞可以在脱髓鞘病毒模型中替代α T细胞，并进一步支持γ δ T细胞在多发性硬化患者中的病理作用。
Infection of mice with mouse hepatitis virus (MHV), strain JHM, results in acute and chronic demyelination with many similarities to the human disease multiple sclerosis. This pathological process is primarily T cell-mediated and MHV infection of mice lacking B and T cells does not result in demyelination. In apparent contradiction to these results, robust demyelination is detected in MHV-infected young nude (athymic) mice. Herein, we show that demyelination in nude mice was mediated by gammadelta T cells. These cells, but not conventional CD4 or CD8 alphabeta T cells, were detected in the central nervous system of MHV-infected nude mice and their depletion with neutralizing antibody resulted in an 80% reduction in demyelination. These results show, for the first time, that gammadelta T cells can substitute for alphabeta T cells in a virus model of demyelination and further support a pathological role for gammadelta T cells in patients with multiple sclerosis.