Gene regulation of prominin-1 (CD133) in normal and cancerous tissues.
Gene regulation of prominin-1 (CD133) in normal and cancerous tissues.
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正常和癌组织中 prominin-1 (CD133) 的基因调控。
DOI：
10.1007/978-1-4614-5894-4_5
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
and S. Tanaka
中科院分区：
文献类型：
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作者：
K. Tabu;N. Bizen;T. Taga;and S. Tanaka
尽管在某些类型的分化细胞中也有表达，但作为一种表面标记物，五翼蛋白膜糖蛋白-1(在人类中经常被称为CD133)被广泛用于从各种器官中鉴定和分离正常的干/祖细胞。自从CD133被认为是从多个组织来源的肿瘤中分离肿瘤干细胞的通用标记以来，其基因调控与肿瘤干细胞特性(即肿瘤干性)之间的关系受到了人们的关注。Prominin-1(PROM1)基因有5个可选的启动子，在5‘-非翻译区(UTR)产生多个第一外显子，也有影响开放阅读框架(ORF)序列的剪接变体，这意味着复杂的基因调控是一种上下文相关的方式。这一章的目的是组织积累的关于AR-1的发现，重点是它在正常细胞和癌细胞中的表达和调控的改变，并讨论潜在的调控网络在癌症干细胞中的作用。
A pentaspan membrane glycoprotein prominin-1 (frequently called CD133 in human) is widely used as a surface marker to identify and isolate normal stem/progenitor cells from various organs, although it is also expressed in some types of differentiated cells. Since CD133 was identified as a universal marker to isolate cancer stem cells (CSCs) in tumors derived from multiple tissues, much attention has been directed toward the relationship between its gene regulation and identity of CSCs (i.e., cancer stemness).Prominin-1(PROM1) gene possesses five alternative promoters yielding multiple first exons within the 5′-untranslated region (UTR) and also splicing variants affecting the open reading frame (ORF) sequence, implicating the complicated gene regulation in a context-dependent manner. This chapter aims to organize the accumulated findings on prominin-1 with a focus on its altered expression and regulation in normal and cancerous cells and to discuss potential regulatory networks underlying cancer stemness.