Soy consumption and prostate cancer risk in men: a revisit of a meta-analysis
Soy consumption and prostate cancer risk in men: a revisit of a meta-analysis
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DOI：
10.3945/ajcn.2008.27029
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发表时间：
2009-04-01
影响因子：
7.1
通讯作者：
Spitznagel, Edward L.
中科院分区：
文献类型：
--
作者：
Yan, Lin;Spitznagel, Edward L.
背景资料：流行病学研究表明，大豆食品的消费可能与降低癌症的风险在human.Objective：本研究的目的是进行荟萃分析之间的关联大豆消费和前列腺癌的风险在男性。设计：我们系统地回顾了通过全面的Medline文献检索获得的研究，并确定了15篇关于大豆消费的流行病学出版物和9篇关于大豆酮的流行病学出版物，与前列腺癌风险的关系。我们从每项研究中提取了最高和最低报告摄入量类别的最大调整相对风险（RR）和比值比（OR），并使用随机效应模型进行了分析，在该模型中，具有较小SE的研究在汇总测量中具有更大的权重。（95% CI：0.63，0.89; P = 0.01）。当单独分析时，非发酵大豆食品的研究得出的合并RR/OR为0.70（95% CI：0.56，0.88; P = 0.01），发酵大豆食品的研究得出的合并RR/OR为1.02（95% CI：0.73，1.42; P = 0.92）。对阿糖胞苷研究的分析得出的合并RR/OR为0.88（95% CI：0.76，1.02; P = 0.09）。进一步的单独分析显示，合并RR/OR为0.52（95% CI：0.34，0.81; P = 0.01）来自亚洲人群研究，0.99（95%CI：0.85，1.16; P = 0.91）。结论：这项分析的结果表明，大豆食品的消费与男性前列腺癌风险的降低有关。这种保护可能与大豆食品的类型和数量有关。美国临床营养杂志2009;89：1155-63。
Background: Epidemiologic studies have shown that the consumption of soy foods may be associated with a reduction in cancer risk in humans.Objective: The purpose of this study was to conduct a metaanalysis on the association between soy consumption and prostate cancer risk in men.Design: We systematically reviewed studies obtained through a thorough Medline literature search and identified 15 epidemiologic publications on soy consumption and 9 on isoflavones in association with prostate cancer risk. We extracted the most adjusted relative risks (RRs) and odds ratios (ORs) of the highest and the lowest reported categories of intake from each study and conducted this analysis using a random-effects model in which studies with smaller SEEs are given greater weight in the summary measure.Results: Our analysis of studies on soy intake yielded a combined RR/OR of 0.74 (95% CI: 0.63, 0.89; P = 0.01). When separately analyzed, studies on nonfermented soy foods yielded a combined RR/OR of 0.70 (95% CI: 0.56, 0.88; P = 0.01) and those on fermented soy foods yielded a combined RR/OR of 1.02 (95% CI: 0.73, 1.42; P = 0.92). The analysis of studies on isoflavones yielded a combined RR/OR of 0.88 (95% CI: 0.76, 1.02; P = 0.09). Further separate analyses showed a combined RR/OR of 0.52 (95% CI: 0.34, 0.81; P = 0.01) from studies with Asian populations and 0.99 (95% CI: 0.85, 1.16; P = 0.91) from studies with Western populations.Conclusions: The results of this analysis suggest that consumption of soy foods is associated with a reduction in prostate cancer risk in men. This protection may be associated with the type and quantity of soy foods consumed. Am J Clin Nutr 2009;89:1155-63.