The use of botulinum toxin for the treatment of temporomandibular disorders: Preliminary findings
The use of botulinum toxin for the treatment of temporomandibular disorders: Preliminary findings
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DOI：
10.1016/s0278-2391(99)90007-1
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发表时间：
1999-08-01
影响因子：
1.9
通讯作者：
Symington, JM
中科院分区：
文献类型：
--
作者：
Freund, B;Schwartz, M;Symington, JM
目的：本研究的目的是评估颞下颌疾病患者对肉毒毒素A （BTX-A）治疗的反应。方法：将15名受试者纳入本非对照研究，进行诊断分类并给予150单位BTX-A治疗。在肌电图（EMG）指导下，两个咬肌各接受50个单位的治疗。同样，两侧颞肌各注射25个单位。每隔2周对受试者进行评估，共8周。结果测量包括通过视觉模拟量表（VAS）测量主观疼痛、咬合力、内脏开口、触诊压痛和基于多个VAS的功能指数。结果：除咬合力外，注射前评估与四次随访评估均有显著差异（P = 0.05）。没有副作用的报道。结论：BTX-A注射对5个测量结果中的4个有统计学意义的改善，特别是疼痛、功能、开口和压痛。在平均最大自愿收缩或配对相关因素（如年龄、性别、诊断、抑郁指数或发病时间）方面没有发现统计学上显著的变化。
Purpose: The aim of this study was to evaluate the response of patients with temporomandibular disorders to Botulinum toxin A (BTX-A) therapy.Methods: The 15 subjects enrolled in this uncontrolled study were diagnostically categorized and treated with 150 units of BTX-A. Both masseter muscles received 50 units each under eletromyographic (EMG) guidance. Similarly, both temporalis muscles were injected with 25 units each. Subjects were assessed at 2-week intervals for 8 weeks. Outcome measures included subjective pain by visual analog scale (VAS), measurement of bite force, interincisal opening, tenderness to palpation, and a functional index based on multiple VAS.Results: All mean outcome measures, with the exception of bite force, showed a significant (P = .05) difference between the preinjection assessment and the four follow-up assessments. No side effects were reported.Conclusions: BTX-A injections produced a statistically significant improvement in four of five measured outcomes, specifically pain, function, mouth opening, and tenderness. No statistically significant changes were found in mean maximum voluntary contraction or in paired correlation of factors such as age, sex, diagnosis, depression index, or time of onset.