TSLC1 tumour-suppressor gene expression in canine mast cell tumours.
TSLC1 tumour-suppressor gene expression in canine mast cell tumours.
复制标题
犬肥大细胞肿瘤中的 TSLC1 肿瘤抑制基因表达。
DOI：
10.1111/j.1476-5829.2010.00220.x
复制
发表时间：
2010
影响因子：
2.1
通讯作者：
T. Scase
中科院分区：
文献类型：
--
作者：
F. Taylor;S. Murphy;T. Hoather;J. Dobson;T. Scase
肺癌肿瘤抑制因子-1(TSLC1)是一种肿瘤抑制基因，编码一种由肥大细胞表达的黏附分子。在几种人类肿瘤中，TSLc1表达降低与预后不良有关，本研究试图探讨TSLc1表达是否可用于预测患有肥大细胞肿瘤(MCT)的犬的预后。用免疫组织化学方法检测45只犬(第1组)不同肿瘤级别的MCT中TSLC1和Ki67的表达。此外，来自已知临床随访的35只中等级别的MCT(组2)进行了TSLC1和Ki67的免疫组织化学染色。在第1组中，TSLC1值与肿瘤分级呈显著负相关(P=0.002857)。对于第二组，有一种趋势，即TSLC1值较低的狗更有可能死于与MCT相关的疾病(P=0.058)。两组TSLC1染色强度与Ki67表达呈负相关。
Tumour suppressor in lung cancer-1 (TSLC1) is a tumour-suppressor gene coding for an adhesion molecule that is expressed by mast cells. Reduced TSLC1 expression is associated with a poor prognosis in several human tumours, and this study sought to investigate if TSLC1 expression could be used to predict outcome in dogs with mast cell tumours (MCTs). Sections of MCTs of different tumour grades from 45 dogs (Group 1) were immunohistochemically assessed for TSLC1 and Ki67 expression. In addition, 35 intermediate-grade MCTs (Group 2) from dogs with known clinical follow-up were immunohistochemically stained for TSLC1 and Ki67. The TSLC1 staining intensity was found to strongly inversely correlate with tumour grade for Group 1 (P = 0.002857). For Group 2 there was a trend towards dogs with lower TSLC1 scores being more likely to die from MCT-related disease (P = 0.058). The intensity of TSLC1 staining inversely correlated with Ki67 expression for both groups.
影响因子：
2.6
作者：
London, CA;Galli, SJ;Geissler, EN
通讯作者：
Geissler, EN