Synthesis of the Tetracyclic Core of Tetrapetalone A Enabled by a Pyrrole Reductive Alkyation
Synthesis of the Tetracyclic Core of Tetrapetalone A Enabled by a Pyrrole Reductive Alkyation
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DOI：
10.1021/ol1018536
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发表时间：
2010-10-15
期刊：
影响因子：
5.2
通讯作者：
Sarpong, Richmond
中科院分区：
文献类型：
--
作者：
Marcus, Andrew P.;Sarpong, Richmond
四酮 A 苷元的四环骨架已通过合成得到固定。还原性吡咯烷基化能够形成关键的四取代碳立构中心，并且分子的特特拉姆酸部分可以通过硅或硼酸酯缀合物加成到烯-内酰胺上来获得
The tetracyclic framework of the tetrapetalone A aglycon has been secured through synthesis A reductive pyrrole alkylation enables the formation of a key tetrasubstituted carbon stereocenter, and the tetramic acid portion of the molecule can be accessed through silicon or boronic ester conjugate addition to an ene-lactam