Effect of Clonorchis sinensis infection and dimethylnitrosamine administration on the induction of cholangiocarcinoma in Syrian golden hamsters
Effect of Clonorchis sinensis infection and dimethylnitrosamine administration on the induction of cholangiocarcinoma in Syrian golden hamsters
复制标题
DOI：
10.3347/kjp.1993.31.1.21
复制
发表时间：
1993-01-01
影响因子：
--
通讯作者：
Bak, Ung-Bok
中科院分区：
文献类型：
--
作者：
Lee, Jae-Hyun;Rim, Han-Jong;Bak, Ung-Bok
本研究观察了中华支气管吸虫感染对叙利亚金黄地鼠胆管癌诱发的影响。第11周观察胆管和肝细胞的组织病理学变化。用DMN处理后再感染C.中华绒螯蟹感染后10周发生胆管癌。sinensis。胆管癌病变特征为胆管上皮腺瘤样或乳头状增生，表现为明显的间变性改变，伴有粘液细胞化生和坏死区。在接受DMN或C.单独的中华白海豚，肝脏仅显示胆管上皮细胞的增生性改变。提出C.中华按蚊感染和DMN给药对金黄地鼠胆管癌的发生有协同作用。
The study was carried out to observe the effects of Clonorchis sinensis infection on induction of cholangiocarcinoma in Syrian golden hamsters to which 15 ppm dimethylnitrosamine (DMN) solution was administered for 8 weeks. The histopathological changes of the bile duct and liver cells were observed at the 11th week. In six of 8 hamsters (75%) which were treated with DMN and then infected with C. sinensis, the livers developed cholangiocarcinoma at 10 weeks after the infestation of C. sinensis. The features of cholangiocarcinoma lesions were adenomatous or papillary hyperplasia of the bile duct epithelia showing distinct anaplastic changes with mucinous cell metaplasia and necrotic area. In the hamsters which received either DMN or C. sinensis alone, the livers showed only hyperplastic changes of the bile duct epithelial cells. It was suggested that C. sinensis infection and DMN administration could be a synergism on the development of cholangiocarcinoma in Syrian golden hamsters.