DEM analysis of particle adhesion during powder mixing for dry powder inhaler formulation development
DEM analysis of particle adhesion during powder mixing for dry powder inhaler formulation development
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DOI：
10.1007/s10035-013-0405-0
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发表时间：
2013-03
期刊：
影响因子：
2.4
通讯作者：
Jiecheng Yang;Chuan-Yu Wu;M. Adams
中科院分区：
文献类型：
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作者：
Jiecheng Yang;Chuan-Yu Wu;M. Adams
了解干粉吸入器 (DPI) 中活性药物成分 (API) 颗粒和载体颗粒之间的粘附相互作用对于配方开发和工艺设计至关重要。在当前的研究中，采用考虑颗粒粘附的离散元方法来研究 DPI 中的附着过程。提出了临界速度准则来确定两个弹性自粘球形颗粒在冲击过程中相互反弹的最低冲击速度。此外，还研究了 API 细颗粒在振动容器中粘附到大载体上的过程。研究发现，存在最佳的振动速度振幅和频率，可以使与载体接触的颗粒数量（即接触数量）最大化。振动过程中的冲击次数和脱离次数均随着振幅和频率的增加而增加，而粘着效率则随着振幅和频率的增加而降低。
Understanding the adhesive interactions between active pharmaceutical ingredient (API) particles and carrier particles in dry powder inhalers (DPIs) is critical for the development of formulations and process design. In the current study, a discrete element method, which accounts for particle adhesion, is employed to investigate the attachment processes in DPIs. A critical velocity criterion is proposed to determine the lowest impact velocity at which two elastic autoadhesive spherical particles will rebound from each other during impact. Furthermore, the process of fine API particles adhering to a large carrier in a vibrating container is investigated. It was found that there are optimal amplitude and frequency for the vibration velocity that can maximise the number of particles contacting with the carrier (i.e. the contact number). The impact number and detachment number during the vibration process both increase with increasing vibration amplitude and frequency while the sticking efficiency decreases as the amplitude and frequency are increased.