VOLUNTARY FINGER MOVEMENT IN MAN - CEREBRAL POTENTIALS AND THEORY
VOLUNTARY FINGER MOVEMENT IN MAN - CEREBRAL POTENTIALS AND THEORY
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DOI：
10.1007/bf00336013
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发表时间：
1976-01-01
影响因子：
1.9
通讯作者：
KORNHUBER, HH
中科院分区：
文献类型：
--
作者：
DEECKE, L;GROZINGER, B;KORNHUBER, HH
通过时间倒置平均法，从颅骨表面记录了手指随意快速屈曲前的三种不同的脑电位。单侧运动前的早期皮质活动是双侧的和广泛的(Bereitschaft Spotential，BP)。第二个电位(运动前正性，PMP)也是如此。只有第3个电位(运动电位，MP)是单侧的，仅限于对侧运动皮质。在总共对39名受试者进行的87项实验中，血压在手指快速屈曲之前平均开始750ms(SD 360，SE 38.5)。其最大波幅出现在顶中，平均为-5.3-V(SD 2.32，SE 0.4)。这样的幅度被发现，每个实验的平均动作为800次或更多。在实验开始时，BP更大。PMP是在收缩肌肉(EMG)的第一个动作电位(EMG)之前90-80ms出现的下一个电位(x=87，SD 34.2，SE 2.95)。在85%的受试者中发现了这种情况。PMP在顶中的最大平均幅度为+1.7-V(SD 1.6，SE 0.28)。较短和相对恒定的起效时间表明，PMP可能反映了与研究中实际引导的快速手指运动的启动有关的皮质活动(运动指令)。在激动剂EMG中，第一次活动前60-50ms(x=54，SD 19.4，SE 3.1)的MP是最后出现的，也是唯一的单侧电位：其定位局限于运动手指对侧的运动皮质的手部区域。在双极记录中，对侧对同侧中央前或对侧中央前对顶，它似乎是一种明显的附加负性。这一额外的负值平均为-1.3微伏(SD 0.64 SE 0.08)。MP反映了运动前的运动皮质活动。在运动开始后，记录到一个复杂的电位，也可以看到被动的手指运动，主要代表躯体感觉(本体感觉)诱发的反应。结合中枢运动功能理论，讨论了运动相关电位的可能意义。
Three different brain potentials preceding voluntary rapid finger flexion were recorded from the skull surface by time reversed averaging. The early cortical activity preceding unilateral movement was bilateral and widespread (Bereitschaftspotential, BP). The same was true for the 2nd potential (pre-motion positivity, PMP). Only the 3rd potential (motor potential, MP) was unilateral and restricted to the contralateral motor cortex. In a total of 87 experiments with 39 subjects the BP started, on the average, 750 ms (SD 360, SE 38.5) prior to rapid finger flexion. Its largest amplitude was found mid-parietally and averaged -5.3 .mu.V (SD 2.32, SE 0.4). Such amplitudes were found with averages of 800 and more movements per experiment. At the beginning of an experiment the BP was larger. The PMP is the next potential occurring 90-80 ms (.hivin.x = 87, SD 34.2, SE 2.95) prior to the 1st action potential in the contracting muscle (EMG). It was found in 85% of the subjects. The PMP has at its maximum, mid-parietally, a mean amplitude of + 1.7 .mu.V (SD 1.6, SE 0.28). The short and the relatively constant onset time suggests that the PMP might reflect cortical activity (motor command) related to initiation of the tactually guided rapid finger movement under study. The MP starting 60-50 ms (.hivin.x = 54, SD 19.4, SE 3.1) prior to 1st activity in the agonist EMG is the last potential to occur and is the only unilateral potential: its localization is limited to the hand area of the motor cortex contralateral to the moving finger. In bipolar recordings, contralateral vs. ipsilateral precentral or contralateral precentral vs. vertex, it appears as a sharp additional negativity. This additional negativity averaged -1.3 .mu.V (SD 0.64 SE 0.08). The MP reflects the motor cortical activity immediately preceding the movement. After movement onset a complex potential was recorded that was also seen with passive finger movement, largely representing a somatosensory (proprioceptive) evoked response. The possible meaning of the movement-related potentials is discussed in relation to a theory of central motor function.