Requisite role of Angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis
Requisite role of Angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis
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DOI：
10.1016/s0092-8674(00)81813-9
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发表时间：
1996-12-27
期刊：
影响因子：
64.5
通讯作者：
Yancopoulos, GD
中科院分区：
文献类型：
--
作者：
Suri, C;Jones, PF;Yancopoulos, GD
血管内皮生长因子（VEGF）通过一个内皮特异性受体酪氨酸激酶家族的成员起作用，是唯一一个明确显示在胚胎血管形成中起作用的因子。只有另一个受体酪氨酸激酶家族，包括TIE1和TIE2，主要是内皮细胞特异性的。我们最近克隆了TIE2的配体，称为血管生成素-1。在这里，我们展示了缺乏血管生成素-1的小鼠显示出血管生成缺陷，这让人想起以前在缺乏TIE2的小鼠中看到的血管生成缺陷，这表明血管生成素-1是TIE2的主要生理配体，它在体内具有与VEGF不同的关键血管生成作用，并且在用于表征VEGF的经典体外试验中没有反映出来。血管生成素-1似乎在介导内皮与周围基质和间质之间的相互作用中起着至关重要的作用。
Vascular endothelial growth factor (VEGF), which acts via members of a family of endothelial-specific receptor tyrosine kinases, is the only factor that has been shown definitively to play a role in the formation of the embryonic vasculature. Only one other family of receptor tyrosine kinases, comprising TIE1 and TIE2, is largely endothelial cell specific. We have recently cloned a ligand for TIE2, termed Angiopoietin-1. Here we show that mice engineered to lack Angiopoietin-1 display angiogenic deficits reminiscent of those previously seen in mice lacking TIE2, demonstrating that Angiopoietin-1 is a primary physiologic ligand for TIE2 and that it has critical in vivo angiogenic actions that are distinct from VEGF and that are not reflected in the classic in vitro assays used to characterize VEGF. Angiopoietin-1 seems to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme.