Lone AF - Etiologic Factors and Genetic Insights into Pathophysiolgy.
Lone AF - Etiologic Factors and Genetic Insights into Pathophysiolgy.
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DOI：
10.4022/jafib.236
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发表时间：
2010-06
影响因子：
--
通讯作者：
Darbar D
中科院分区：
文献类型：
--
作者：
Parvez B;Darbar D
自从40多年前首次在年轻人中发现心房颤动（AF）（所谓的“孤立性”AF）以来，人们越来越关注确定该疾病的潜在病理生理学。虽然孤立性房颤被认为是一种高度异质性的疾病，但最近的研究已经确定了心律失常的新风险因素，如炎症，氧化应激，耐力运动和遗传学。这本专著的目的是突出一些最近的进展，我们的理解的分子病理生理学的孤立性房颤，特别是洞察力所提供的当代遗传学研究。这些见解可能为年轻患者治疗这种具有挑战性的心律失常提供新的治疗靶点。
Ever since atrial fibrillation (AF) was first recognized in young people (so called “lone” AF) over 4 decades ago, there has been increasing focus on determining the underlying the pathophysiology of the condition. Although lone AF is presumed to be a highly heterogeneous disease, recent studies have identified novel risk factors such as inflammation, oxidative stress, endurance sports and genetics, for the arrhythmia. This monograph aims to highlight some of the recent advances in our understanding of the molecular pathophysiology of lone AF especially insight provided by contemporary genetic studies. These insights may provide novel therapeutic targets for treatment of this challenging arrhythmia in young patients.