Low activity of superoxide dismutase and high activity of glutathione reductase in erythrocytes from centenarians
Low activity of superoxide dismutase and high activity of glutathione reductase in erythrocytes from centenarians
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DOI：
10.1093/ageing/27.5.643
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发表时间：
1998-09-01
期刊：
影响因子：
6.7
通讯作者：
Grandjean, P
中科院分区：
文献类型：
--
作者：
Andersen, HR;Jeune, B;Grandjean, P
目的：比较百岁老人和年轻组老年受试者红细胞中抗氧化酶的活性。设计：横断面研究。设置：丹麦的Funen县。受试者：41名年龄在100和105岁之间的百岁老人和52名年龄在60和79岁之间的社区对照受试者。测量：红细胞超氧化物歧化酶（CuZn-SOD）、谷胱甘肽过氧化物酶、过氧化氢酶和谷胱甘肽还原酶（GR）的酶活性。结果：百岁老人的CuZn-SOD活性显著低于老年组，GR活性显著高于老年组，而CuZn-SOD活性显著低于老年组，GR活性显著高于老年组。认知和身体功能能力最低的百岁老人以及采血后未存活1年的百岁老人的CuZn-SOD活性最低。GR活性的范围被转移到更高的值在百岁老人组比在年轻的组和那些百岁老人具有最好的功能能力往往有最高的GR activity.Conclusions：CuZn-SOD活性降低百岁老人，可能是因为在较低的代谢率和耗氧量的酶的需求减少。具有高GR活性的受试者在百岁老人中发生的频率比预期的要高，这可能是由于他们的生存率更高。GR在疾病预防中的作用以及作为长寿的预测因子值得进一步探讨。
Objective: to compare the activities of antioxidative enzymes in erythrocytes between centenarians and a younger group of elderly subjects.Design: cross-sectional study.Setting: county of Funen, Denmark.Subjects: 41 centenarians aged between 100 and 105 years and 52 community control subjects aged between 60 and 79 years.Measurements: enzyme activities of superoxide dismutase (CuZn-SOD), glutathione peroxidase, catalase and glutathione reductase (GR) in erythrocytes. Functional capacity among the centenarians was evaluated by Katz' index of activities of daily living, the Physical Performance Test and Mini-Mental State Examination.Results: the mean CuZn-SOD activity was significantly lower and the mean GR activity was significantly higher in centenarians than in the group of elderly people. The centenarians with the lowest cognitive and physical functional capacity and who did not survive at least 1 year after blood sampling tended to have the lowest CuZn-SOD activities. The range of GR activity was shifted toward higher values in the centenarian group than in the younger group and those centenarians having the best functional capacity tended to have the highest GR activity.Conclusions: CuZn-SOD activity is decreased in centenarians, probably because of reduced demand for the enzyme at lower metabolic rate and oxygen consumption. Subjects with high GR activity occur more frequently among centenarians than expected, possibly due to their better survival. The role of GR in disease prevention and as a predictor for longevity deserves to be further explored.