Role of vitamin d in the prevention of pancreatic cancer.
Role of vitamin d in the prevention of pancreatic cancer.
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DOI：
10.1155/2010/721365
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发表时间：
2010
影响因子：
2.2
通讯作者：
Saif MW
中科院分区：
文献类型：
--
作者：
Bulathsinghala P;Syrigos KN;Saif MW
胰腺癌是一种预后不良的恶性肿瘤，大多在晚期才被诊断出来。目前的治疗方式非常有限，这引起了人们对新的预防和治疗选择的极大兴趣。维生素D似乎通过参与多种促凋亡、抗血管生成、抗炎、增殖和免疫调节机制，对胰腺癌具有保护作用。25-羟基维生素D [25(OH)D]血清浓度是目前维生素D状态的最佳指标。维生素D有三种主要来源：阳光照射、饮食和膳食补充剂。生态学研究表明，阳光照射与胰腺癌发病率降低有关。增加维生素D水平似乎可以预防胰腺癌，但需要谨慎，因为过量的饮食摄入可能会产生相反的结果。未来的研究将验证维生素D在预防和治疗胰腺癌中的作用，并将制定适当的阳光照射和维生素D饮食摄入量的指南。
Pancreatic cancer is a malignancy of poor prognosis which is mostly diagnosed at advanced stages. Current treatment modalities are very limited creating great interest for novel preventive and therapeutic options. Vitamin D seems to have a protective effect against pancreatic cancer by participating in numerous proapoptotic, antiangiogenic, anti-inflammatory, prodifferentiating, and immunomodulating mechanisms. 25-hydroxyvitamin D [25(OH)D] serum concentrations are currently the best indicator of vitamin D status. There are three main sources of vitamin D: sun exposure, diet,and dietary supplements. Sun exposure has been associated with lower incidence of pancreatic cancer in ecological studies. Increased vitamin D levels seem to protect against pancreatic cancer, but caution is needed as excessive dietary intake may have opposite results. Future studies will verify the role of vitamin D in the prevention and therapy of pancreatic cancer and will lead to guidelines on adequate sun exposure and vitamin D dietary intake.