New immune connections in osteoclast formation
New immune connections in osteoclast formation
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DOI：
10.1111/j.1749-6632.2009.05303.x
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发表时间：
2010-01-01
期刊：
影响因子：
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通讯作者：
Takayanagi, Hiroshi
中科院分区：
文献类型：
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作者：
Takayanagi, Hiroshi
骨免疫学是一个跨学科的研究领域，在分子水平上研究骨骼和免疫系统的相互作用。免疫细胞与破骨细胞之间的相互作用一直是该领域的主要课题。由于破骨细胞来源于单核细胞/巨噬细胞谱系，因此巨噬细胞破骨细胞相互作用已经研究了很长时间。T细胞与破骨细胞的相互作用在关节炎骨破坏的研究中也引起了广泛的关注。此外，最近的报告揭示了连接破骨细胞和其他免疫细胞的新参与者，包括B细胞和树突细胞。因此，破骨细胞和免疫细胞实际上共享大量的分子。这些发现将导致更好地了解影响这两个系统的疾病的发病机制，并为新的治疗策略提供分子基础。
Osteoimmunology is an interdisciplinary research field that investigates the interplay of the skeletal and immune systems at the molecular level. The interaction between immune cells and osteoclasts has been a major topic in this field. As osteoclasts are derived from the monocyte/macrophage lineage, the macrophage osteoclast interaction has long been studied. The T cell osteoclast interaction has also attracted much attention in the study of bone destruction in arthritis. In addition, recent reports have revealed new players linking osteoclasts and other immune cells, including B cells and dendritic cells. Thus, a large number of molecules are in fact shared by osteoclasts and immune cells. These findings will lead to a better understanding of the pathogenesis of diseases affecting both systems and will provide a molecular basis for novel therapeutic strategies.