Genetic background differences between FVB and C57BL/6 mice affect hypnotic susceptibility to pentobarbital, ketamine and nitrous oxide, but not isoflurane
Genetic background differences between FVB and C57BL/6 mice affect hypnotic susceptibility to pentobarbital, ketamine and nitrous oxide, but not isoflurane
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DOI：
10.1111/j.1399-6576.2006.001002.x
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发表时间：
2006-05-01
影响因子：
2.1
通讯作者：
Kobayashi, E
中科院分区：
文献类型：
--
作者：
Sato, Y;Seo, N;Kobayashi, E
背景：药物基因组学使我们能够确定药物反应中许多遗传可变性的潜在机制。已有多篇报道表明，不同麻醉剂对啮齿动物的催眠和抗伤害作用存在显著的遗传差异。方法：采用翻正反射丧失的方法，比较了C57BL/6黑毛小鼠和FVB白发小鼠对戊巴比妥、氯胺酮、一氧化二氮和异氟醚的催眠作用。结果：C57BL/6小鼠比FVB小鼠对氯胺酮、氯胺酮、一氧化二氮和异氟醚的催眠作用更敏感。然而，C57BL/6小鼠和FVB小鼠对异氟醚的敏感性没有差异。结论：遗传背景影响小鼠对某些麻醉剂的催眠敏感性。我们的结果表明，异氟醚和其他麻醉剂如戊巴比妥、氯胺酮和一氧化二氮可能有不同的催眠操作的遗传基础。
Background: Pharmacogenomics has allowed us to identify the mechanisms underlying much of the inherited variability in drug response. There have been several reports of strain-dependent anesthetic actions in rodents, indicating that significant genetic differences exist in the hypnotic and antinociceptive effects of various anesthetics.Methods: Loss of righting reflex was used to compare the hypnotic action of pentobarbital, ketamine, nitrous oxide and isoflurane between two genetically different populations of mice, C57BL/6 with black hair and Friends virus B (FVB) with white hair.Results: C57BL/6 mice were more susceptible than FVB mice to the hypnotic effects of ketamine, pentobarbital and nitrous oxide. However, the sensitivity to isoflurane did not differ between C57BL/6 and FVB mice.Conclusion: Genetic background affects the hypnotic susceptibility to some anesthetic agents in mice. Our results indicate that there may be a different genetic basis for the operation of hypnosis between isoflurane and other anesthetics, such as pentobarbital, ketamine and nitrous oxide.