Paracrine relationships between adipose and lymphoid tissues: implications for the mechanism of HIV-associated adipose redistribution syndrome
Paracrine relationships between adipose and lymphoid tissues: implications for the mechanism of HIV-associated adipose redistribution syndrome
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DOI：
10.1016/s1471-4906(02)00004-2
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发表时间：
2003-01-01
影响因子：
16.8
通讯作者：
Pond, CM
中科院分区：
文献类型：
--
作者：
Pond, CM
解剖学上与淋巴结和网膜乳白斑相关的脂肪细胞具有位点特异性，使其能够与淋巴细胞局部相互作用。外周免疫反应的旁分泌提供提高了其效率，并使活化的淋巴细胞免于与其他组织竞争血液营养物质。这种旁分泌相互作用的长期破坏可能会导致艾滋病毒相关的脂肪重新分布综合征，导致肠系膜、大网膜和其他含有淋巴组织的脂肪库选择性肥大，而无淋巴结库萎缩。
The adipocytes anatomically associated with lymph nodes and omental milky spots have site-specific properties that equip them to interact locally with lymphoid cells. Paracrine provisioning of peripheral immune responses improves their efficiency and emancipates activated lymphocytes from competition with other tissues for blood-borne nutrients. Prolonged disruption to such paracrine interactions might contribute to the HIV-associated adipose redistribution syndrome, causing selective hypertrophy of the mesentery, omentum and other lymphoid tissue-containing adipose depots, while nodeless depots atrophy.