Effective treatment of cutaneous and subcutaneous malignant tumours by electrochemotherapy.
Effective treatment of cutaneous and subcutaneous malignant tumours by electrochemotherapy.
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DOI：
10.1038/bjc.1998.388
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发表时间：
1998-06
影响因子：
8.8
通讯作者：
Heller, R
中科院分区：
文献类型：
--
作者：
Mir, L M;Glass, L F;Sersa, G;Teissie, J;Domenge, C;Miklavcic, D;Jaroszeski, M J;Orlowski, S;Reintgen, D S;Rudolf, Z;Belehradek, M;Gilbert, R;Rols, M P;Belehradek, J Jr;Bachaud, J M;DeConti, R;Stabuc, B;Cemazar, M;Coninx, P;Heller, R
电化学疗法（ECT）通过与短强电脉冲结合给药来增强化疗药物的有效性。 ECT 之所以有效，是因为电脉冲可渗透肿瘤细胞膜，并允许博莱霉素等非渗透性药物进入细胞。本研究的目的是证明 ECT 联合博莱霉素对皮肤和皮下肿瘤的抗肿瘤功效。本文总结了五个癌症中心进行的独立临床试验所获得的结果。 50例患者共治疗291例皮肤或皮下肿瘤，包括基底细胞癌（32例）、恶性黑色素瘤（142例）、腺癌（30例）和头颈鳞状细胞癌（87例）。静脉内或肿瘤内施用博来霉素后，经皮向肿瘤施加短而强的电脉冲。治疗后 30 天测量肿瘤并评估治疗反应。在接受 ECT 治疗的 273 个可评估肿瘤中，有 233 个（85.3%）获得了客观缓解。 154 个（56.4%）肿瘤获得临床完全缓解，79 个（28.9%）肿瘤获得部分缓解。对患者施加电脉冲是安全且耐受性良好的。注意到下面的肌肉瞬时收缩。观察到最小的不良副作用。 ECT被证明是一种有效的局部治疗方法。无论肿瘤的组织学类型如何，ECT 都是有效的。因此，ECT 提供了一种不良副作用最小且反应率高的治疗患者皮肤和皮下肿瘤的方法。
Electrochemotherapy (ECT) enhances the effectiveness of chemotherapeutic agents by administering the drug in combination with short intense electric pulses. ECT is effective because electric pulses permeabilize tumour cell membranes and allow non-permeant drugs, such as bleomycin, to enter the cells. The aim of this study was to demonstrate the anti-tumour effectiveness of ECT with bleomycin on cutaneous and subcutaneous tumours. This article summarizes results obtained in independent clinical trials performed by five cancer centres. A total of 291 cutaneous or subcutaneous tumours of basal cell carcinoma (32), malignant melanoma (142), adenocarcinoma (30) and head and neck squamous cell carcinoma (87) were treated in 50 patients. Short and intense electric pulses were applied to tumours percutaneously after intravenous or intratumour administration of bleomycin. The tumours were measured and the response to the treatment evaluated 30 days after the treatment. Objective responses were obtained in 233 (85.3%) of the 273 evaluable tumours that were treated with ECT. Clinical complete responses were achieved in 154 (56.4%) tumours, and partial responses were observed in 79 (28.9%) tumours. The application of electric pulses to the patients was safe and well tolerated. An instantaneous contraction of the underlying muscles was noticed. Minimal adverse side-effects were observed. ECT was shown to be an effective local treatment. ECT was effective regardless of the histological type of the tumour. Therefore, ECT offers an approach to the treatment of cutaneous and subcutaneous tumours in patients with minimal adverse side-effects and with a high response rate.