MR imaging contrast enhancement based on intermolecular zero quantum coherences
MR imaging contrast enhancement based on intermolecular zero quantum coherences
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DOI：
10.1126/science.281.5374.247
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发表时间：
1998-07-10
期刊：
影响因子：
56.9
通讯作者：
Leigh, JS
中科院分区：
文献类型：
--
作者：
Warren, WS;Ahn, S;Leigh, JS
报道了一种基于从分子间零量子相干(IZQCs)中探测到较强信号的磁共振成像(MRI)的新方法。这样的信号在传统的磁共振框架下是观察不到的；它起源于传统上被忽视的长程偶极耦合(10微米到1毫米)。与常规MRI不同的是，图像对比度是基于自旋密度和松弛时间的变化(通常使用对比剂)，而iZQC图像的对比度来自于由梯度强度决定的距离上的敏感度变化。体模和活体(大鼠脑)数据证实，iZQC图像具有对比度增强作用。这种对比在检测小肿瘤方面可能很有用，因为敏感性与氧气浓度和功能磁共振相关。
A new method for magnetic resonance imaging (MRI) based on the detection of relatively strong signal from intermolecular zero-quantum coherences (iZQCs) is reported. Such a signal would not be observable in the conventional framework of magnetic resonance; it originates in Long-range dipolar couplings (10 micrometers to 1 millimeter) that are traditionally ignored. Unlike conventional MRI, where image contrast is based on variations in spin density and relaxation times (often with injected contrast agents), contrast with iZQC images comes from variations in the susceptibility over a distance dictated by gradient strength. phantom and in vivo (rat brain) data confirm that iZQC images give contrast enhancement. This contrast might be useful in the detection of small tumors, in that susceptibility correlates with oxygen concentration and in functional MRI.