The action of bile salts on viruses.
The action of bile salts on viruses.
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DOI：
10.1002/path.1700480309
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发表时间：
1939-05-01
期刊：
影响因子：
--
通讯作者：
Smith, W
中科院分区：
文献类型：
--
作者：
Smith, W
某些胆汁盐能够灭活某些病毒，但对其他病毒没有明显影响。灭活几乎是瞬时的，并且被认为取决于病毒元件的裂解。脱氧胆酸钠和阿胆胆酸钠是所研究的胆汁盐中活性最强的，前者的活性约为后者的 4 倍。胆酸钠仅具有轻微的活性。病毒对胆盐的敏感性与其大小无关。胆汁盐裂解过程可以通过可培养的胸膜肺炎病毒样生物以及莱德劳和埃尔福德的污水生物在宏观和微观上观察到。使用裂解病毒制剂进行预防性免疫的尝试并不令人鼓舞。
Certain bile salts are able to inactivate some viruses but have no apparent effect upon others. The inactivation is almost instantaneous and is thought to depend upon lysis of the virus elements. Na deoxycholate and Na apocholate are the most active of the bile salts investigated, the former being about 4 times as active as the latter. Na cholate possesses only slight activity. The susceptibility of a virus to bile salts is not related to its size. The process of bile-salt lysis can be observed both macroscopically and microscopically with the cultivable virus-like organism of pleuropneumonia and the sewage organisms of Laidlaw and Elford. Attempts to use lysed virus preparations for prophylactic immunization have not been encouraging.