Evolution of gene expression in the Drosophila melanogaster subgroup
Evolution of gene expression in the Drosophila melanogaster subgroup
复制标题
DOI：
10.1038/ng1086
复制
发表时间：
2003-02-01
期刊：
影响因子：
30.8
通讯作者：
White, KP
中科院分区：
文献类型：
--
作者：
Rifkin, SA;Kim, J;White, KP
在任何发育过程中基因表达的变化和进化的广泛模式知之甚少。在这里，我们调查果蝇simulans，果蝇yakuba和四个品系的果蝇在一个主要的发展转变变态的开始全基因组基因表达的变化。这些谱系之间的基因活性差异遵循系统发育模式，并且这些基因组中所有基因的27%在至少两个菌株或物种之间的发育基因表达不同。我们确定，在一个基因的基础上，形成这种变化的进化力量，并表明，无论是在控制变态的转录网络和整个基因组，转录因子基因的表达变化是相对稳定的，而他们的下游目标更有可能已经演变。我们的研究结果表明，密切相关的物种之间的发育基因表达的广泛进化。
Little is known about broad patterns of variation and evolution of gene expression during any developmental process. Here we investigate variation in genome-wide gene expression among Drosophila simulans, Drosophila yakuba and four strains of Drosophila melanogaster during a major developmental transition-the start of metamorphosis. Differences in gene activity between these lineages follow a phylogenetic pattern, and 27% of all of the genes in these genomes differ in their developmental gene expression between at least two strains or species. We identify, on a gene-by-gene basis, the evolutionary forces that shape this variation and show that, both within the transcriptional network that controls metamorphosis and across the whole genome, the expression changes of transcription factor genes are relatively stable, whereas those of their downstream targets are more likely to have evolved. Our results demonstrate extensive evolution of developmental gene expression among closely related species.