Insulin and Proinsulin Dynamics Progressively Deteriorate From Within the Normal Range Toward Impaired Glucose Tolerance
Insulin and Proinsulin Dynamics Progressively Deteriorate From Within the Normal Range Toward Impaired Glucose Tolerance
复制标题
DOI：
10.1210/jendso/bvaa066
复制
发表时间：
2020-07-01
影响因子：
4.1
通讯作者：
Nagasaka, Shoichiro
中科院分区：
文献类型：
--
作者：
Murai, Norimitsu;Saito, Naoko;Nagasaka, Shoichiro
内容：血糖（PG）的轻微升高在糖尿病发病前就已显现，但在此阶段免疫反应性胰岛素（IRI）、胰岛素原（Pro）和脂联素动力学的异常仍知之甚少。目的：这项工作的目的是调查IRI和Pro动力学是否会随着糖耐量从正常范围内向糖耐量受损（IGT）恶化而变得异常，以及PC与这些动力学和血清脂联素水平之间的关系。设计：设计了一项横断面研究。设置：本研究在日本自治医科大学进行。参与者和测量：在1311名日本年轻人中测定PG、IRI和Pro水平在75-g口服葡萄糖耐量试验期间，在30、60和120分钟之前和在30、60和120分钟时具有正常或IGT的受试者（年龄< 40岁）。根据糖耐量将受试者分为4组，然后测定背景因素、脂联素水平、胰岛素敏感性（SI）和胰岛素分泌（β）指数。结果：葡萄糖负荷后60和120分钟，PG水平以及IRI和Pro水平随糖耐量的恶化而递增。所有的β和胰岛素敏感性（ISI）的SI测量指数-松田逐步下降。血清脂联素水平之间没有显着差异的葡萄糖耐量组，但独立和负相关的空腹glucose.Conclusions：早期β下降和后负荷Pro水平变得过度，在一个渐进的方式作为葡萄糖耐量恶化，从正常范围内对IGT。(C)内分泌学会2020年。
Context: Slight elevations in plasma glucose (PG) manifest in advance of diabetes onset, but abnormalities in immunoreactive insulin (IRI), proinsulin (Pro), and adiponectin dynamics during this stage remain poorly understood.Objective: The objective of this work is to investigate whether IRI and Pro dynamics become abnormal as glucose tolerance deteriorates from within the normal range toward impaired glucose tolerance (IGT), as well as the relationship between PC, and these dynamics and serum adiponectin levels.Design: A cross-sectional study was designed.Setting: This study took place at Jichi Medical University in Japan.Participants and Measurements: PG, IRI, and Pro levels were determined in 1311 young Japanese individuals (age < 40 years) with normal or IGT before and at 30, 60, and 120 minutes during a 75-g oral glucose tolerance test. Participants were assigned to 4 groups according to glucose tolerance, and then background factors, adiponectin levels, insulin sensitivity (SI), and insulin secretion (beta) indexes were determined.Results: PG levels as well as IRI and Pro levels 60 and 120 minutes after glucose-loading increased incrementally with deteriorating glucose tolerance. All measures of beta and the SI measure index of insulin sensitivity (ISI)-Matsuda decreased incrementally. Serum adiponectin levels were not significantly different among the glucose tolerance groups, but were independently and negatively correlated with fasting glucose.Conclusions: Early beta decreased and postloading Pro levels became excessive in a progressive manner as glucose tolerance deteriorated from within the normal range toward IGT. (C) Endocrine Society 2020.