Temporal changes in blood product usage in preterm neonates born at less than 30 weeks' gestation in Canada
Temporal changes in blood product usage in preterm neonates born at less than 30 weeks' gestation in Canada
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DOI：
10.1111/trf.12998
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发表时间：
2015-06-01
期刊：
影响因子：
2.9
通讯作者：
Shah, Prakesh S.
中科院分区：
文献类型：
--
作者：
Keir, Amy K.;Yang, Junmin;Shah, Prakesh S.
背景对新生儿输血实践的了解仍然仅限于当地队列或基于调查的研究。本研究评估了加拿大妊娠不足 30 周的早产儿使用血液制品的类型和频率的模式和时间变化。 研究设计和方法 对 2004 年至 2012 年入住加拿大新生儿网络的新生儿重症监护病房的妊娠不足 30 周的早产儿进行回顾性队列研究，以评估血液制品的使用情况。通过将研究期分为三个时期来评估红细胞 (RBC) 使用的时间变化：2004 年至 2006 年、2007 年至 2009 年和 2010 年至 2012 年。 结果在整个研究期间，加拿大参与单位收治的 14,868 名符合条件的新生儿中，8252 名（56%）接受了红细胞，2151 名（15%）接受了红细胞。血小板、1556 (11%) 新鲜冰冻血浆、915 (6%) 白蛋白和 302 (2%) 冷沉淀。三个时期的时间评估揭示了妊娠 26 至 29 周出生的新生儿红细胞输血次数减少的趋势 (p=
BACKGROUNDKnowledge of neonatal transfusion practices remains limited to local cohorts or survey-based studies. This study evaluated the pattern and temporal changes in the types and frequency of blood product use among preterm neonates born at less than 30 weeks' gestation in Canada.STUDY DESIGN AND METHODSA retrospective cohort study of preterm neonates born at less than 30 weeks' gestation and admitted to participating neonatal intensive care units in the Canadian Neonatal Network from 2004 to 2012 was conducted to evaluate blood product usage. The temporal change in red blood cell (RBC) use was evaluated by dividing the study period into three epochs: 2004 to 2006, 2007 to 2009, and 2010 to 2012.RESULTSOf 14,868 eligible neonates admitted to participating units in Canada during the overall study period, 8252 (56%) received RBCs, 2151 (15%) platelets, 1556 (11%) fresh-frozen plasma, 915 (6%) albumin, and 302 (2%) cryoprecipitate. Temporal evaluation over three epochs revealed a trend toward fewer RBC transfusions among neonates born at 26 to 29 weeks' gestation (p=