Cerebral desaturation during exercise reversed by O2 supplementation
Cerebral desaturation during exercise reversed by O2 supplementation
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DOI：
10.1152/ajpheart.1999.277.3.h1045
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发表时间：
1999-09-01
影响因子：
4.8
通讯作者：
Secher, NH
中科院分区：
文献类型：
--
作者：
Nielsen, HB;Boushel, R;Secher, NH
使用近红外光谱测定过度通气和动脉去饱和对脑氧合（Sc-O2）的综合影响。11名竞争性桨手进行了6分钟的最大测力计行。该研究以双盲方式随机化，交叉设计中的吸入O-2分数为0.21或0.30。在吸入O2分数为0.21的运动期间，动脉CO2压（35 +/- 1 mmHg;平均值+/- SE）和O2压（77 +/- 2 mmHg）以及血红蛋白饱和度（91.9 +/- 0.7%）降低（P < 0.05）。Scot从80 +/- 2降低到63 +/- 2%（P < 0.05），近红外光谱测定的股外侧肌的脱氧血红蛋白（Delta Hb）和氧合血红蛋白（Delta HbO（2））的浓度变化分别增加了22 +/- 3 μ M和减少了14 +/- 3 μ M（P < 0.05）。将吸入Oz分数增加至0.30并不影响通气量（174 +/- 41/min），但动脉CO2压（37 +/- 2 mmHg）、O-2压（165 +/- 5 mmHg）和血红蛋白Oz饱和度（99 +/- 0.1%）增加（P < 0.05）。斯考特在运动过程中保持接近休息水平（79 +/- 2 vs. 81 +/- 2%），虽然肌肉δ Hb（18 +/- 2 I-IM）和Delta HbO（2）（-12 +/-3 μ M）与未补充O-2时相似，做功能力从389 +/-11增加到413 +/-10 W（P < 0.05）。这些结果表明，吸气O-2分数的升高增加了与维持脑氧合相关的运动表现，而不是对工作肌肉的影响。
The combined effects of hyperventilation and arterial desaturation on cerebral oxygenation (Sc-O2) were determined using near-infrared spectroscopy. Eleven competitive oarsmen were evaluated during a 6-min maximal ergometer row. The study was randomized in a double-blind fashion with an inspired O-2 fraction of 0.21 or 0.30 in a crossover design. During exercise with an inspired O-2 fraction of 0.21, the arterial CO2 pressure (35 +/- 1 mmHg; mean +/- SE) and O-2 pressure (77 +/- 2 mmHg) as well as the hemoglobin saturation (91.9 +/- 0.7%) were reduced (P < 0.05). Scot was reduced from 80 +/- 2 to 63 +/- 2% (P < 0.05), and the near-infrared spectroscopy-determined concentration changes in deoxy- (Delta Hb) and oxyhemoglobin (Delta HbO(2)) of the vastus lateralis muscle increased 22 +/- 3 mu M and decreased 14 +/- 3 mu M, respectively (P < 0.05). Increasing the inspired Oz fraction to 0.30 did not affect ventilation (174 +/- 41/min), but arterial CO2 pressure (37 +/- 2 mmHg), O-2 pressure (165 +/- 5 mmHg), and hemoglobin Oz saturation (99 +/- 0.1%) increased (P < 0.05). Scot remained close to the resting level during exercise (79 +/- 2 vs. 81 +/- 2%), and although the muscle Delta Hb (18 +/- 2 I-IM) and Delta HbO(2) (-12 +/- 3 mu M) were similar to those established without O-2 supplementation, work capacity increased from 389 +/- 11 to 413 +/- 10 W (P < 0.05). These results indicate that an elevated inspiratory O-2 fraction increases exercise performance related to maintained cerebral oxygenation rather than to an effect on the working muscles.