MOLECULAR-FORMS OF ACETYLCHOLINESTERASE IN SENILE DEMENTIA OF ALZHEIMER TYPE - SELECTIVE LOSS OF THE INTERMEDIATE (10S) FORM
MOLECULAR-FORMS OF ACETYLCHOLINESTERASE IN SENILE DEMENTIA OF ALZHEIMER TYPE - SELECTIVE LOSS OF THE INTERMEDIATE (10S) FORM
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DOI：
10.1016/0304-3940(83)90302-6
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发表时间：
1983-01-01
影响因子：
2.5
通讯作者：
FAIRBAIRN, A
中科院分区：
文献类型：
--
作者：
ATACK, JR;PERRY, EK;FAIRBAIRN, A
采用密度梯度离心法，对正常人和老年性阿尔茨海默型痴呆（SDAT）患者死后新皮层乙酰胆碱酯酶的3种分子形式进行了区分。虽然在SDAT中轻和重形式的水平没有改变，但中间形式有选择性和广泛的损失。这种形式主要是疏水性的，其从SDAT的大脑皮层的损失可能反映胆碱能轴突过程的变性。这是中枢神经系统疾病中乙酰胆碱酯酶分子形式分布改变的首次报道。
Using density gradient centrifugation, 3 molecular forms of acetylcholinesterase were distinguished in both normal and senile dementia of Alzheimer-type (SDAT) postmortem neocortex. While the levels of the light and heavy forms were unaltered in SDAT there was a selective and extensive loss of the intermediate form. This form is predominantly hydrophobic and its loss from the cerebral cortex in SDAT may reflect degeneration of cholinergic axonal processes. This is the 1st report of an altered distribution of acetylcholinesterase molecular forms in a disease of the CNS.