Altered Functional Connectivity of the Basal Nucleus of Meynert in Mild Cognitive Impairment: A Resting-State fMRI Study.
Altered Functional Connectivity of the Basal Nucleus of Meynert in Mild Cognitive Impairment: A Resting-State fMRI Study.
复制标题
轻度认知障碍中 Meynert 基底核功能连接的改变：静息态功能磁共振成像研究
DOI：
10.3389/fnagi.2017.00127
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发表时间：
2017
影响因子：
4.8
通讯作者：
Li K
中科院分区：
文献类型：
--
作者：
Li H;Jia X;Qi Z;Fan X;Ma T;Ni H;Li CR;Li K
背景：胆碱能功能障碍在轻度认知功能障碍(MCI)中起重要作用。Meynert基底核(BNM)是皮质胆碱能神经支配的主要来源。以前的研究已经表征了阿尔茨海默病(AD)高危人群的胆碱能基底前脑的结构变化。然而，MCI中BNM(BNM-Fc)的功能连接是否以及如何改变仍是未知的。目的：本研究的目的是确定与健康对照组(HCS)相比，MCI患者BNM-Fc的改变，并探讨这些改变与MCI患者神经心理指标之间的关系。方法：对101例轻度脑梗塞和10 3例肥厚性脑出血患者进行静息状态功能磁共振成像。成像数据用SPM8和Conn软件进行处理。通过BNM和所有其他脑体素之间的低频fMRI信号波动的相关性来检验BNM-FC。以年龄、性别、教育程度、平均框架位移(FD)和全球相关性(GCOR)为干扰协变量，用协方差分析检验组内差异。采用皮尔逊相关分析评价BNM-FC与临床评估的关系。结果：与HCS相比，MCI患者左侧脑岛延伸至屏蔽区(岛/屏蔽区)的BNM-FC显著降低。此外，MCI患者在听觉言语学习测验(AVLT)中，脑岛/屏蔽区BNM-FC的下降幅度越大，即刻回忆能力的损害越严重。结论：MCI与BNM-Fc到脑岛/屏核的改变有关，与认知功能障碍有关。这些新的发现可能会推动对健康老龄化期间认知功能障碍的胆碱能基础的研究，以及对有患阿尔茨海默病风险的人的研究。
Background: Cholinergic dysfunction plays an important role in mild cognitive impairment (MCI). The basal nucleus of Meynert (BNM) provides the main source of cortical cholinergic innervation. Previous studies have characterized structural changes of the cholinergic basal forebrain in individuals at risk of developing Alzheimer’s disease (AD). However, whether and how functional connectivity of the BNM (BNM-FC) is altered in MCI remains unknown. Objective: The aim of this study was to identify alterations in BNM-FC in individuals with MCI as compared to healthy controls (HCs), and to examine the relationship between these alterations with neuropsychological measures in individuals with MCI. Method: One-hundred-and-one MCI patients and 103 HCs underwent resting-state functional magnetic resonance imaging (rs-fMRI). Imaging data were processed with SPM8 and CONN software. BNM-FC was examined via correlation in low frequency fMRI signal fluctuations between the BNM and all other brain voxels. Group differences were examined with a covariance analysis with age, gender, education level, mean framewise displacement (FD) and global correlation (GCOR) as nuisance covariates. Pearson’s correlation was conducted to evaluate the relationship between the BNM-FC and clinical assessments. Result: Compared with HCs, individuals with MCI showed significantly decreased BNM-FC in the left insula extending into claustrum (insula/claustrum). Furthermore, greater decrease in BNM-FC with insula/claustrum was associated with more severe impairment in immediate recall during Auditory Verbal Learning Test (AVLT) in MCI patients. Conclusion: MCI is associated with changes in BNM-FC to the insula/claustrum in relation to cognitive impairments. These new findings may advance research of the cholinergic bases of cognitive dysfunction during healthy aging and in individuals at risk of developing AD.