Salivary secretions: narcolepsy and central nervous system stimulants.
Salivary secretions: narcolepsy and central nervous system stimulants.
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唾液分泌物：发作性睡病和中枢神经系统兴奋剂。
DOI：
10.1177/00220345980770100901
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发表时间：
1998
影响因子：
7.6
通讯作者：
Jensen,JL
中科院分区：
文献类型：
--
作者：
Nordgarden,H;Lamkin,M;Oppenheim,FG;Storhaug,K;Jensen,JL
为了建立一个模型来研究各种疾病和药物对唾液的影响，我们对接受中枢神经系统兴奋剂治疗的发作性睡病患者进行了研究。目的是研究中枢神经系统兴奋剂存在和不存在时发作性睡病患者唾液蛋白的分泌。为此，我们选择了两种在腺泡细胞中合成的蛋白质，即富含脯氨酸的酸性蛋白(PRPS)和施他宁。入选单纯中枢神经系统兴奋剂治疗的发作性睡病患者12例，年龄14~68岁，女性7例。这些人在服药期间采集柠檬酸刺激的腮腺和下颌/舌下/舌下唾液样本，在停药一周后，再次使用药物后至少两周，以及来自匹配的健康对照组。用反相色谱和阴离子交换层析法分别测定PRP和他汀类药物的浓度。在接受中枢神经系统刺激剂治疗的发作性睡病患者中，与健康对照组相比，他汀类药物和PRPS的浓度和产量均增加。当药物停用时，唾液流率没有受到影响。相反，停药导致PRPS和他汀类药物的分泌显著减少。蛋白质分泌的减少可能反映了发作性睡病患者肾上腺素能激活的降低，而中枢神经系统兴奋剂的治疗可以逆转这一现象。可以得出结论，唾液和唾液蛋白质的测量对于全面评估特定药物或疾病对唾液分泌的影响可能是必要的。
In an ongoing attempt to develop a model to study the influence of various diseases and drugs on saliva, we studied persons with narcolepsy treated with central nervous system stimulants. The aim was to study the secretion of salivary proteins in narcolepsy in the presence and absence of central nervous system stimulants. For this purpose, two proteins synthesized in acinar cells, acidic proline-rich proteins (PRPs) and statherin, were selected. Persons with narcolepsy treated with central nervous system stimulants only were included, n = 12, ages 14 to 68, seven females. Citric-acid-stimulated parotid and submandibular/sublingual saliva samples were collected from these persons during medication, after a drug-free period of one week, at least two weeks after the drug had been re-introduced, and from a matched healthy control group. PRP and statherin concentrations were determined by means of reversed-phase and anion exchange chromatography, respectively. Both concentration and output of statherins and PRPs were increased in persons with narcolepsy receiving central nervous system stimulants compared with healthy control individuals. When the drug was withdrawn, salivary flow rates were not influenced. In contrast, withdrawal of the drug led to a significantly decreased secretion of PRPs and statherin. The reduced protein secretion may reflect decreased adrenergic activation in narcolepsy, to be reversed by treatment with central nervous system stimulants. It can be concluded that measurements of both salivary fluid and salivary proteins may be necessary for an overall evaluation of the effects of a given drug or disease on salivary secretion.