Polymorphisms of the ADAM33 gene and chronic obstructive pulmonary disease risk: a meta- analysis
Polymorphisms of the ADAM33 gene and chronic obstructive pulmonary disease risk: a meta- analysis
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DOI：
10.1111/crj.12046
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发表时间：
2014-01-01
影响因子：
1.7
通讯作者：
Wufuer, Dilinuer
中科院分区：
文献类型：
--
作者：
Aierken, Haidiya;Wang, Jing;Wufuer, Dilinuer
研究背景解整合素和金属蛋白酶（ADAM 33）基因T1（rs 2280091）、S1（rs3918396）和S2（rs 528557）多态性与慢性阻塞性肺疾病（COPD）易感性有关。但是，一些研究报告了不确定的结果。本研究旨在通过Meta分析探讨ADAM 33基因T1（rs 2280091）、S1（rs3918396）和S2（rs 528557）多态性与COPD发病风险的关系。统计分析采用METAGEN（STATA 12.0）软件和Revman5.0软件。结果共纳入10个病例对照研究的2139例COPD患者和3765例对照者。结果表明，S2（rs 528557）和T1（rs 2280091）多态性不会导致COPD风险的增加或降低。本报告中描述的分析表明，S1（rs3918396）多态性（GG+AG vs AA）与总体和亚洲人显著相关。比值比（OR）（总）=1.27 [95%置信区间（CI）1.03-1.56，P=0.03]，ORAsian=1.44（95% CI 1.13-1.83，P=0.003），但没有与高加索人。结论这项荟萃分析表明，S1 ADAM 33基因rs3918396多态性与亚洲人（中国）COPD风险增加相关，但与白人无关。需要进一步的研究来验证我们的结论。
BackgroundThe T1 (rs2280091), S1 (rs3918396) and S2 (rs528557) polymorphisms in a disintegrin and metalloprotease (ADAM33) gene has been implicated in susceptibility of chronic obstructive pulmonary disease (COPD). But, a number of studies have reported inconclusive results. The aim of this study is to investigate the relationship between T1 (rs2280091), S1 (rs3918396) and S2 (rs528557) polymorphisms in ADAM33 gene and COPD risk by meta-analysis.MethodsWe searched Pubmed database, Embase database, Chinese National Knowledge Infrastructure database and Wanfang database, covering all studies till September 5, 2012. Statistical analysis was performed using software METAGEN (STATA 12.0) and Revman5.0.ResultsA total of 2139 COPD cases and 3765 controls in 10 case-control studies were included in this study. The results showed that S2 (rs528557) and T1 (rs2280091) polymorphisms did not result in an increased or a decreased risk of COPD. The analysis described in this report demonstrated that S1 (rs3918396) polymorphism (GG+AG vs AA) was significantly associated with the total and Asian. Odds ratio (OR)(total)=1.27 [95% confidence interval (CI) 1.03-1.56, P=0.03], ORAsian=1.44 (95% CI 1.13-1.83, P=0.003) but not with Caucasians.ConclusionsThis meta-analysis suggested that S1 (rs3918396) polymorphism of ADAM33 is associated with increased risk of COPD in Asian (China) but not in Caucasians. Future studies are needed to validate our conclusions.