Do cells make decisions based on uncertainty in their biochemical networks?
Do cells make decisions based on uncertainty in their biochemical networks?
复制标题
细胞是否根据其生化网络的不确定性做出决策？
DOI：
10.1016/j.bpj.2013.04.009
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发表时间：
2013
影响因子：
3.4
通讯作者：
Kraikivski,Pavel
中科院分区：
文献类型：
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作者：
Kraikivski,Pavel
在酵母细胞上收集数据的新方法挑战了计算生物学家在不同尺度上解开细胞内复杂系统的行为。在一篇发表在《生物物理学杂志》上的文章中，Li et al. (1)基于统计物理学的经典思想，提出了一种新的方法来分析决定细胞命运的竞争分子途径。在有利的条件下，酵母细胞通过一个称为出芽的过程快速生长和分裂，在这个过程中，一个新的子细胞从母细胞中出芽。大多数新的生长进入花蕾，因为母细胞复制其染色体并将新的细胞核挤压到花蕾中。当DNA合成和核分裂的过程完成时，芽从母细胞中分离出来，开始自己的独立存在。将一个细胞分成两个细胞的这一系列过程称为“细胞周期”。单倍体酵母细胞（只有一组染色体），可以以这种方式生长和分裂（有丝分裂细胞周期），具有另一种命运，即阻止细胞周期进展并与交配伴侣进行性接合。在过去的几十年中，通过分子遗传学和计算建模（2-7）对酵母中的细胞周期进程和交配停滞进行了广泛的研究，使酵母细胞成为细胞命运决定的分子机制的吸引人的案例研究。
New methods of data collection on yeast cells have challenged computational biologists to unravel complex system behavior within cells at different scales. In an article appearing in the Biophysical Journal, Li et al.(1) propose a novel way to analyze competing molecular pathways that determine alternative cell fates, based on classical ideas from statistical physics.Under favorable conditions, yeast cells grow and divide rapidly by a process called budding, in which a new daughter cell buds off the parent cell. Most new growth goes into the bud, as the mother cell replicates its chromosomes and extrudes a new nucleus into the bud. When this process of DNA synthesis and nuclear division is complete, the bud separates from the mother cell and begins its own separate existence. This series of events that makes one cell into two is called the ‘‘cell cycle’’. Haploid yeast cells (having only one set of chromosomes), which can grow and divide in this fashion (mitotic cell cycles), have an alternative fate, which is to arrest cell-cycle progression and undergo sexual conjugation with a mating partner. Cell-cycle progression and mating arrest in yeast have been studied extensively during the last few decades by molecular genetics and computational modeling (2–7), making yeast cells an appealing case study of molecular mechanisms of cell-fate determination.