Why size really matters when sequencing plant genomes
Why size really matters when sequencing plant genomes
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DOI：
10.1080/17550874.2012.716868
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发表时间：
2012-12-01
影响因子：
1.5
通讯作者：
Leitch, Ilia J.
中科院分区：
文献类型：
--
作者：
Kelly, Laura J.;Leitch, Andrew R.;Leitch, Ilia J.
基因组测序仅限于具有小基因组大小的物种。随着第二代和第三代测序技术的出现，对各种大小的基因组进行测序的潜力正在成为现实。随着全基因组测序领域的发展，人们越来越认识到需要更好地代表植物生命树的主要谱系，而不仅仅是那些包含经济上重要分类群的谱系。我们认为，在选择物种进行分析时，除了考虑系统发育多样性外，为了全面了解基因组进化，大规模测序项目还需要反映植物基因组大小的多样性。在本文中，我们简要概述了文献证据来支持这一观点。
Genome sequencing has been restricted to species with a small genome size. With the advent of second- and third-generation sequencing technologies, the potential to sequence genomes of all sizes is becoming a reality. As the field of whole genome sequencing has developed, there has been a growing appreciation of the need to better represent the major lineages of the plant tree of life, rather than just those that contain economically important taxa. We argue that as well as accounting for phylogenetic diversity when selecting species to analyse, in order to gain a comprehensive understanding of genome evolution, large-scale sequencing projects also need to reflect the diversity of genome sizes in plants. In this article we briefly outline evidence from the literature to support this view.