The health and social environment of uninfected infants born to HIV-infected women
The health and social environment of uninfected infants born to HIV-infected women
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DOI：
10.1080/09540120410001665303
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发表时间：
2004-04-01
影响因子：
1.7
通讯作者：
Newell, ML
中科院分区：
文献类型：
--
作者：
Hankin, C;Thorne, C;Newell, ML
在欧洲艾滋病毒感染的妇女所生的未感染儿童数量不断增加的背景下，我们描述了社会环境和传染病的发生在1,667名婴儿参加了欧洲合作研究（ECS），并进行了前瞻性随访。在欧洲共同国家，撒哈拉以南非洲黑人妇女所生的儿童中，通过异性性行为感染艾滋病毒的比例自1980年代中期以来有所增加，而北方和南欧有非法吸毒史的白色妇女所生的儿童比例有所下降。接受替代性（非父母）照料的儿童比例从1985-1989年的17%（821 469）下降到1999-2002年的5%（23/436）。共有135名婴儿（随访1,475个儿童年）在出生后第一年至少发生过一次中度/重度感染或发热事件，需要就医;与记录的社会人口学和儿童特征几乎没有相关性。住院率在研究期间保持相对稳定，在每1000儿童年243-299例住院。需要描述未感染儿童的疾病负担和社会环境，不仅因为他们的人数不断增加，而且因为他们经常被用作研究纵向获得性艾滋病毒感染的对照。
Against a background of increasing numbers of uninfected children born to HIV-infected women in Europe, we describe the social environment and occurrence of infectious disease in 1,667 infants enrolled in the European Collaborative Study (ECS) and followed prospectively. In the ECS, the proportion of children born to black women from Sub-Saharan Africa who acquired their HIV infection heterosexually has increased since the mid-1980s, while the proportion of those born to white women with a history of illicit drug use has decreased, in both northern and southern Europe. The percentage of children who had been in alternative (non-parental) care decreased from 17% (821469) in 1985-1989 to 5% (23/436) in 1999-2002. A total of 135 infants (with 1,475 child-years of follow-up) experienced at least one moderate/severe infective or febrile episode requiring medical attention in the first year of life; there was little correlation with recorded sociodemographic and child characteristics. The rate of hospitalization remained relatively stable over the study period at between 243-299 admissions per 1, 000 child-years. Description of disease burden and social circumstances of uninfected children is needed, not only because of their increasing numbers but also because they are often used as controls in studies addressing vertically-acquired HIV infection.