BRAIN REGIONS INFLUENCED BY THE LATERAL PARABRACHIAL NUCLEUS IN ANGIOTENSIN II-INDUCED WATER INTAKE
BRAIN REGIONS INFLUENCED BY THE LATERAL PARABRACHIAL NUCLEUS IN ANGIOTENSIN II-INDUCED WATER INTAKE
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DOI：
10.1016/j.neuroscience.2013.08.027
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发表时间：
2013-11-12
期刊：
影响因子：
3.3
通讯作者：
McKinley, M. J.
中科院分区：
文献类型：
--
作者：
Davern, P. J.;McKinley, M. J.
这项研究检查了哪些大脑区域受到抑制性臂旁外侧核（LPBN）机制的影响，该机制会影响水的摄入。对照组和双侧LPBN病变大鼠给予血管紧张素II（AngII）（0.5 mg/kg.皮下- SC），测量饮水反应，并处理脑用于Fos免疫组织化学。另一组LPBN损伤和未损伤的动物在灌注前90分钟不喝水，以去除任何水摄入的混杂因素。LPBN损伤大鼠的累积饮水量为9 mL，
This study examined which brain regions are influenced by an inhibitory lateral parabrachial nucleus (LPBN) mechanism that affects water intake. Controls and rats with bilateral LPBN lesions were administered angiotensin II (AngII) (0.5 mg/kg. subcutaneous - SC), drinking responses measured, and brains processed for Fos-immunohistochemistry. A separate group of LPBN-lesioned and non-lesioned animals were denied water for 90 min prior to perfusion to remove any confounding factor of water intake. LPBN-Iesioned rats drank a cumulative volume of 9 mL compared with