The global burden of rheumatoid arthritis: estimates from the Global Burden of Disease 2010 study
The global burden of rheumatoid arthritis: estimates from the Global Burden of Disease 2010 study
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DOI：
10.1136/annrheumdis-2013-204627
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发表时间：
2014-07-01
影响因子：
27.4
通讯作者：
March, Lyn
中科院分区：
文献类型：
--
作者：
Cross, Marita;Smith, Emma;March, Lyn
Objectives To estimate the global burden of rheumatoid arthritis（RA），as part of the Global Burden of Disease 2010 study of 291 conditions and how the burden of RA compares with other conditions.Methods The optimal case definition of RA for the study was the American College of Rheumatology 1987 criteria.我们进行了一系列的系统评价，以收集不同年龄、性别的RA患病率、发病率和死亡率的流行病学数据。还包括特定原因的死亡率数据。将数据输入DisMod-MR，这是一种汇总现有数据的工具，利用研究水平协变量调整国家、区域和超区域随机效应，以估计每个国家和一段时间内的流行率。流行病学数据以及残疾加权数被用来计算残疾生活年数。结果1990 ~ 2010年全球RA患病率为0.24%（95%CI 0.23%~ 0.25%），无明显变化。残疾人从1990年的330万（男性）（95%置信区间260万至410万）增加到2010年的480万（95%置信区间370万至610万）。这一增长是由于人口增长和老龄化加剧。在全球范围内，研究的291个条件，类风湿关节炎被列为全球残疾的第42位最高贡献者，仅次于疟疾和碘缺乏症（以YLDs衡量）。结论类风湿关节炎继续造成适度的全球残疾，在个人受影响的严重后果。
Objectives To estimate the global burden of rheumatoid arthritis (RA), as part of the Global Burden of Disease 2010 study of 291 conditions and how the burden of RA compares with other conditions.Methods The optimum case definition of RA for the study was the American College of Rheumatology 1987 criteria. A series of systematic reviews were conducted to gather age-sex-specific epidemiological data for RA prevalence, incidence and mortality. Cause-specific mortality data were also included. Data were entered into DisMod-MR, a tool to pool available data, making use of study-level covariates to adjust for country, region and super-region random effects to estimate prevalence for every country and over time. The epidemiological data, in addition to disability weights, were used to calculate years of life lived with disability (YLDs). YLDs were added to the years of life lost due to premature mortality to estimate the overall burden (disability-adjusted life years (DALYs)) for RA for the years 1990, 2005 and 2010.Results The global prevalence of RA was 0.24% (95% CI 0.23% to 0.25%), with no discernible change from 1990 to 2010. DALYs increased from 3.3 million (M) (95% CI 2.6 M to 4.1 M) in 1990 to 4.8 M (95% CI 3.7 M to 6.1 M) in 2010. This increase was due to a growth in population and increase in aging. Globally, of the 291 conditions studied, RA was ranked as the 42nd highest contributor to global disability, just below malaria and just above iodine deficiency (measured in YLDs).Conclusions RA continues to cause modest global disability, with severe consequences in the individuals affected.