Distinct claudins and associated PDZ proteins form different autotypic tight junctions in myelinating Schwann cells.
Distinct claudins and associated PDZ proteins form different autotypic tight junctions in myelinating Schwann cells.
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DOI：
10.1083/jcb.200207050
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发表时间：
2002-10-28
期刊：
影响因子：
--
通讯作者：
Peles E
中科院分区：
文献类型：
--
作者：
Poliak S;Matlis S;Ullmer C;Scherer SS;Peles E
髓鞘形成的许旺细胞的并置膜由几种类型的连接特化连接，称为自体型或反射性连接。这些连接包括紧密连接、间隙连接和粘附连接，所有这些连接都存在于非致密髓鞘的区域：结旁环、施密特-兰特曼切口和中轴突。自体型紧密连接的分子组成尚未确定。在这里，我们报告，两个同源的光盘丢失多PDZ结构域蛋白（MUPP）1，和PALS相关的紧密连接蛋白（PATJ），差异定位于髓鞘形成的雪旺细胞和相关的不同的claudins。PATJ主要存在于结旁环，在那里它与claudin-1共定位。MUPP 1和claudin-5共定位于切口中，并且claudin-5的COOH-末端区域以PSD-95/Disc Large/Disc occludens（ZO）-1（PDZ）依赖性方式与MUPP 1相互作用。在发育中的神经中，claudin-5和MUPP 1在出生后第一周的切口中一起出现，表明它们在髓鞘形成期间共同组装。最后，我们发现，切口还包含其他四个PDZ蛋白，发现在上皮紧密连接，包括三个膜相关的鸟苷酸激酶蛋白（膜相关的鸟苷酸激酶倒置-2，ZO-1和ZO-2）和衔接蛋白Par-3。这些不同的紧密连接蛋白在非紧密髓鞘区域的存在可能是维持髓鞘化雪旺细胞复杂的细胞结构所必需的。
The apposed membranes of myelinating Schwann cells are joined by several types of junctional specializations known as autotypic or reflexive junctions. These include tight, gap, and adherens junctions, all of which are found in regions of noncompact myelin: the paranodal loops, incisures of Schmidt-Lanterman, and mesaxons. The molecular components of autotypic tight junctions have not been established. Here we report that two homologues of Discs Lost–multi PDZ domain protein (MUPP)1, and Pals-associated tight junction protein (PATJ), are differentially localized in myelinating Schwann cells and associated with different claudins. PATJ is mainly found at the paranodal loops, where it colocalized with claudin-1. MUPP1 and claudin-5 colocalized in the incisures, and the COOH-terminal region of claudin-5 interacts with MUPP1 in a PSD-95/Disc Large/zona occludens (ZO)-1 (PDZ)-dependent manner. In developing nerves, claudin-5 and MUPP1 appear together in incisures during the first postnatal week, suggesting that they coassemble during myelination. Finally, we show that the incisures also contain four other PDZ proteins that are found in epithelial tight junctions, including three membrane-associated guanylate-kinase proteins (membrane-associated guanylate-kinase inverted-2, ZO-1, and ZO-2) and the adaptor protein Par-3. The presence of these different tight junction proteins in regions of noncompact myelin may be required to maintain the intricate cytoarchitecture of myelinating Schwann cells.
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cingulin包含球形和盘绕螺旋域，并与ZO-1，ZO-2，ZO-3和肌球蛋白相互作用。
影响因子：
7.8
作者：
Cordenonsi, M;D'Atri, F;Hammar, E;Parry, D A;Kendrick-Jones, J;Shore, D;Citi, S
通讯作者：
Citi, S
影响因子：
7.8
作者：
Einheber, S;Zanazzi, G;Ching, W;Scherer, S;Milner, TA;Peles, E;Salzer, JL
通讯作者：
Salzer, JL
DOI：
10.1007/bf01159386
发表时间：
1983-01-01
期刊：
JOURNAL OF NEUROCYTOLOGY
影响因子：
--
作者：
BERTHOLD, CH;RYDMARK, M
通讯作者：
RYDMARK, M
影响因子：
8
作者：
Ide, N;Hata, Y;Takai, Y
通讯作者：
Takai, Y
新型的E-钙粘蛋白介导的外周神经：Schwann细胞结构的粘附稳定在自动型粘附连接处。
影响因子：
7.8
作者：
Fannon, A M;Sherman, D L;Ilyina-Gragerova, G;Brophy, P J;Friedrich, V L Jr;Colman, D R
通讯作者：
Colman, D R