Human pluripotent stem cell-derived brain organoids as in vitro models for studying neural disorders and cancer.
Human pluripotent stem cell-derived brain organoids as in vitro models for studying neural disorders and cancer.
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DOI：
10.1186/s13578-021-00617-1
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发表时间：
2021-05-28
影响因子：
7.5
通讯作者：
Li P
中科院分区：
文献类型：
--
作者：
Luo J;Li P
大脑的复杂性和人类脑组织资源的有限性极大地阻碍了我们对大脑疾病和癌症的理解。最近开发的三维（3D）脑类器官（BO）是自组织的，并在体外自发地从人类多能干细胞（hPSC）分化而来，其表现出与发育中的人脑相似的细胞类型多样性，结构组织和功能连接的特征。基于这些特性，hPSC衍生的BO（hPDBO）提供了新的机会，以在体外再现脑发育、神经退行性疾病和脑癌期间的复杂过程。本文将对现有的BO模型进行综述，并总结该技术在神经系统疾病和癌症建模中的应用。此外，我们将讨论与其作为疾病建模的体外模型的使用和潜在的未来方向相关的挑战。
The sheer complexities of brain and resource limitation of human brain tissue greatly hamper our understanding of the brain disorders and cancers. Recently developed three-dimensional (3D) brain organoids (BOs) are self-organized and spontaneously differentiated from human pluripotent stem cells (hPSCs) in vitro, which exhibit similar features with cell type diversity, structural organization, and functional connectivity as the developing human brain. Based on these characteristics, hPSC-derived BOs (hPDBOs) provide new opportunities to recapitulate the complicated processes during brain development, neurodegenerative disorders, and brain cancers in vitro. In this review, we will provide an overview of existing BO models and summarize the applications of this technology in modeling the neural disorders and cancers. Furthermore, we will discuss the challenges associated with their use as in vitro models for disease modeling and the potential future direction.
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影响因子：
11
作者：
Alić I;Goh PA;Murray A;Portelius E;Gkanatsiou E;Gough G;Mok KY;Koschut D;Brunmeir R;Yeap YJ;O'Brien NL;Groet J;Shao X;Havlicek S;Dunn NR;Kvartsberg H;Brinkmalm G;Hithersay R;Startin C;Hamburg S;Phillips M;Pervushin K;Turmaine M;Wallon D;Rovelet-Lecrux A;Soininen H;Volpi E;Martin JE;Foo JN;Becker DL;Rostagno A;Ghiso J;Krsnik Ž;Šimić G;Kostović I;Mitrečić D;LonDownS Consortium;Francis PT;Blennow K;Strydom A;Hardy J;Zetterberg H;Nižetić D
通讯作者：
Nižetić D
影响因子：
23.9
作者：
Dost AFM;Moye AL;Vedaie M;Tran LM;Fung E;Heinze D;Villacorta-Martin C;Huang J;Hekman R;Kwan JH;Blum BC;Louie SM;Rowbotham SP;Sainz de Aja J;Piper ME;Bhetariya PJ;Bronson RT;Emili A;Mostoslavsky G;Fishbein GA;Wallace WD;Krysan K;Dubinett SM;Yanagawa J;Kotton DN;Kim CF
通讯作者：
Kim CF
影响因子：
48
作者：
Bian S;Repic M;Guo Z;Kavirayani A;Burkard T;Bagley JA;Krauditsch C;Knoblich JA
通讯作者：
Knoblich JA
影响因子：
64.5
作者：
Andersen J;Revah O;Miura Y;Thom N;Amin ND;Kelley KW;Singh M;Chen X;Thete MV;Walczak EM;Vogel H;Fan HC;Paşca SP
通讯作者：
Paşca SP
影响因子：
4.3
作者：
Bejoy, Julie;Yuan, Xuegang;Li, Yan
通讯作者：
Li, Yan