HTR1B, ADIPOR1, PPARGC1A, and CYP19A1 and Obesity in a Cohort of Caucasians and African Americans: An Evaluation of Gene-Environment Interactions and Candidate Genes
HTR1B, ADIPOR1, PPARGC1A, and CYP19A1 and Obesity in a Cohort of Caucasians and African Americans: An Evaluation of Gene-Environment Interactions and Candidate Genes
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DOI：
10.1093/aje/kwr272
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发表时间：
2012-01-01
影响因子：
5
通讯作者：
Matthews, Charles E.
中科院分区：
文献类型：
--
作者：
Edwards, Todd L.;Edwards, Digna R. Velez;Matthews, Charles E.
世界卫生组织估计，肥胖和超重的成年人人数已增加到16亿人，伴随着肥胖人数的增加。虽然肥胖的遗传因素在高加索人中得到了广泛的研究，但很少有研究调查非裔美国人体重指数（BMI;体重（kg）/身高（m）（2））的遗传决定因素。在南方社区队列研究（2002-2009）中，对非裔美国人（n = 1，173）中的38个基因和1，086个单核苷酸多态性（SNP）以及高加索人（n = 1，165）中的897个SNP进行了检查，以确定其与BMI和基因x环境相互作用的相关性。在非裔美国人中，在rs 4140535的多重检验校正后，与BMI存在统计学显著相关性（β =-0.04，95%置信区间：-0.06，-0.02; P = 5.76 x 10（-5）），但在高加索人中没有。在非裔美国人中观察到吸烟和ADIPOR 1中的SNP之间的基因-环境相互作用，以及在高加索人中ADIPOR 1中的不同SNP和体力活动之间的基因-环境相互作用。PPARGC 1A中的SNP与非裔美国人的饮酒量相互作用，而PPARGC 1A中的另一种SNP与高加索人名义上相关。CYP 19 A1中的一个SNP与非裔美国人的膳食能量摄入相互作用，而CYP 191 A中的另一个SNP与高加索人的BMI独立相关。
The World Health Organization estimates that the number of obese and overweight adults has increased to 1.6 billion, with concomitant increases in comorbidity. While genetic factors for obesity have been extensively studied in Caucasians, fewer studies have investigated genetic determinants of body mass index (BMI; weight (kg)/height(m)(2)) in African Americans. A total of 38 genes and 1,086 single nucleotide polymorphisms (SNPs) in African Americans (n = 1,173) and 897 SNPs in Caucasians (n = 1,165) were examined in the Southern Community Cohort Study (2002-2009) for associations with BMI and gene x environment interactions. A statistically significant association with BMI survived correction for multiple testing at rs4140535 (beta = -0.04, 95% confidence interval: -0.06, -0.02; P = 5.76 x 10(-5)) in African Americans but not in Caucasians. Gene-environment interactions were observed with cigarette smoking and a SNP in ADIPOR1 in African Americans, as well as between a different SNP in ADIPOR1 and physical activity in Caucasians. A SNP in PPARGC1A interacted with alcohol consumption in African Americans, and a different SNP in PPARGC1A was nominally associated in Caucasians. A SNP in CYP19A1 interacted with dietary energy intake in African Americans, and another SNP in CYP191A had an independent association with BMI in Caucasians.