Incidence of diabetes in youth in the United States
Incidence of diabetes in youth in the United States
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DOI：
10.1001/jama.297.24.2716
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发表时间：
2007-06-27
影响因子：
120.7
通讯作者：
Waitzfelder, Beth
中科院分区：
文献类型：
--
作者：
Dabelea, Dana;Bell, Ronny A.;Waitzfelder, Beth
根据种族/民族背景和糖尿病类型，美国青少年糖尿病（DM）发病率的数据有限。目的根据种族/民族和糖尿病类型估计20岁以下青年糖尿病的发病率。设计、环境和参与者：一项多民族、基于人群的研究（The SEARCH for Diabetes in Youth study），在2002年和2003年对2435名新诊断为非继发性糖尿病的年轻人进行了研究，在美国的10个研究地点进行，覆盖人口超过1000万人年。主要结局测量按年龄组、性别、种族/民族和糖尿病类型计算每10万人年的发病率。糖尿病类型（1型/ 2型）基于医疗保健专业人员的分配，在一个亚群中，进一步以谷氨酸脱羧酶（GAD65）自身抗体和空腹C肽检测为特征。结果DM的发病率（每10万人年）为24.3（95%可信区间[CI]， 23.3-25.3）。在10岁以下的儿童中，大多数患有1型糖尿病，无论种族/民族如何。1型糖尿病发病率最高的是非西班牙裔白人青年（0-4岁、5-9岁和10-14岁年龄组分别为18.6、28.1和32.9）。即使在年龄较大的青少年（>= 10岁）中，1型糖尿病在非西班牙裔白人、西班牙裔和非裔美国青少年中也很常见。总体而言，2型糖尿病仍然相对少见，但最高的发病率（17.0至49.4 / 100000人年）记录在15至19岁的少数群体中。结论：我们的数据记录了所有种族/民族青年中1型糖尿病的发病率，其中非西班牙裔白人青年发病率最高。总的来说，2型糖尿病仍然相对少见；然而，在青少年少数民族人群中观察到的比率最高。
Context Data on the incidence of diabetes mellitus (DM) among US youth according to racial/ethnic background and DM type are limited.Objective To estimate DM incidence in youth aged younger than 20 years according to race/ethnicity and DM type.Design, Setting, and Participants A multiethnic, population-based study (The SEARCH for Diabetes in Youth Study) of 2435 youth with newly diagnosed, nonsecondary DM in 2002 and 2003, ascertained at 10 study locations in the United States, covering a population of more than 10 million person-years.Main Outcome Measure Incidence rates by age group, sex, race/ethnicity, and DM type were calculated per 100 000 person-years at risk. Diabetes mellitus type ( type 1/type 2) was based on health care professional assignment and, in a subset, further characterized with glutamicacid decarboxylase( GAD65) autoantibody and fasting C peptide measures.Results The incidence of DM ( per 100 000 person-years) was 24.3 (95% confidence interval [CI], 23.3-25.3). Among children younger than 10 years, most had type 1 DM, regardless of race/ethnicity. The highest rates of type 1 DM were observed in non-Hispanic white youth (18.6, 28.1, and 32.9 for age groups 0-4, 5-9, and 10-14 years, respectively). Even among older youth ( >= 10 years), type 1 DM was frequent among non-Hispanic white, Hispanic, and African American adolescents. Overall, type 2 DM was still relatively infrequent, but the highest rates (17.0 to 49.4 per 100 000 person-years) were documented among 15- to 19-year-old minority groups.Conclusions Our data document the incidence rates of type 1 DM among youth of all racial/ethnic groups, with the highest rates in non-Hispanic white youth. Overall, type 2 DM is still relatively infrequent; however, the highest rates were observed among adolescent minority populations.