Anti-endotoxin and anti-inflammatory effects of Chinese herbal medicinal alkaloid ingredients in vivo
Anti-endotoxin and anti-inflammatory effects of Chinese herbal medicinal alkaloid ingredients in vivo
复制标题
中药生物碱成分体内抗内毒素和抗炎作用
DOI：
10.1016/j.micpath.2016.08.006
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发表时间：
2016-10-01
影响因子：
3.8
通讯作者：
He, Kongwang
中科院分区：
文献类型：
--
作者：
Hu, Yiyi;Mao, Aihua;He, Kongwang
研究了青藤碱、防己诺林碱、水苏碱、川芎嗪、羟马川碱和吴茱萸碱等常见中草药生物碱的抗内毒素和抗炎作用。在内毒素（LPS）对照组中，通过腹膜内（IP）注射用lmg LPS/kg攻击每只小鼠。在高、中、低剂量生物碱组中，小鼠最初通过IP注射1 mg LPS/kg进行攻击，3小时后，以三种水平（1、5或10 mg/kg体重）之一肌肉注射（IM）六种生物碱之一。在药物对照组中，给小鼠IM给予10 mg/kg体重的给定生物碱;给未处理对照组中的小鼠给予相同体积的生理盐水。结果显示，六种生物碱可以降低LPS诱导的毒性的发生率/严重程度，例如，体温升高、体重减轻、全身炎症、多器官功能障碍。总之，这些数据向我们表明，这些生物碱可能有效地调节炎症反应，并有可能用于抗内毒素治疗。(C)2016爱思唯尔有限公司版权所有
The aim of the research was to investigate the anti-endotoxin and anti-inflammatory effects of sinomenine, fangchinoline, stachydrine, chuanxionggzine, oxymartrine, and evodiamine alkaloids commonly found in Chinese herbal medicines. In an endotoxin (LPS) control group, each mouse was challenged with 1 mg LPS/kg by intraperitoneal (IP) injection. In high-, middle- and low-dose alkaloid groups, mice were initially challenged with 1 mg LPS/kg by IP injection and, 3 h later, dosed intramuscularly (IM) with one of the six alkaloids at one of three levels (1, 5, or 10 mg/kg body weight). In the drug control group, mice were dosed IM with 10 mg/kg body weight of a given alkaloid; mice in a naive control group were administered the same volume of normal saline. The results revealed the six alkaloids could reduce the incidence/severity of LPS- induced toxicities, e.g., body temperature elevation, weight loss, systemic inflammation, multiple organ dysfunction. Taken together, the data suggested to us that these alkaloids might effectively regulate inflammatory responses and have a potential to be used in anti-endotoxin therapies. (C) 2016 Elsevier Ltd. All rights reserved.