The efficacy of theophylline in premature infants with mixed and obstructive apnea and apnea associated with pulmonary and neurologic disease.
The efficacy of theophylline in premature infants with mixed and obstructive apnea and apnea associated with pulmonary and neurologic disease.
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茶碱对患有混合性和阻塞性呼吸暂停以及与肺部和神经系统疾病相关的呼吸暂停的早产儿的疗效。
DOI：
10.1016/s0022-3476(82)80530-1
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Thach,BT
中科院分区：
文献类型：
--
作者：
Roberts,JL;Mathew,OP;Thach,BT
由国家卫生研究所第1号赠款ROIHD 10993 -05提供部分支助。转载地址：华盛顿大学医学院儿科，圣路易斯，MO 63 l l~。Dr. John L.罗伯茨和Oommen P. Mathew是美国肺脏协会奖学金培训A病房的获得者。该组出现呼吸暂停。2我们重新评估茶碱治疗早产儿呼吸暂停的疗效有两个原因。(1)既往研究未记录治疗的呼吸暂停类型（即中枢性、混合性或阻塞性）。这些研究中使用的呼吸暂停监测技术可能未能记录涉及气道阻塞的呼吸暂停。(2)在这些早期研究中，未考虑伴发呼吸系统或中枢神经系统疾病的婴儿，尽管这些婴儿代表了呼吸暂停的主要人群。茶碱治疗此类婴儿的唯一报告
Supported in part by the National Institute of Health Grant No. 1 ROIHD10993-05.* Reprint address: Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63l l~. Drs. John L. Roberts and Oommen P. Mathew are recipients of the American Lung Association Fellowship Training A ward. apnea in this group. 2 We have re-evaluated the efficacy of theophylline for apnea in preterm infants for two reasons.(1) Previous studies did not document the types (ie, central, mixed, or obstructive) of apnea treated. The apnea monitoring techniques used in these studies may have failed to record apneas involving airway obstruction.(2) In these earlier studies, infants with concomitant respiratory or central nervous system disease were not considered, although these infants represent a major group with apnea. The only report of theophylline treatment in such infants