Cellular Sensing Governs the Stability of Chemotactic Fronts
Cellular Sensing Governs the Stability of Chemotactic Fronts
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DOI：
10.1103/physrevlett.128.148101
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发表时间：
2022-04-08
影响因子：
8.6
通讯作者：
Datta, Sujit S.
中科院分区：
文献类型：
--
作者：
Alert, Ricard;Martinez-Calvo, Alejandro;Datta, Sujit S.
在从胚胎发育到细菌生态学的背景下，细胞群体沿着自生的化学梯度迁移，通常形成繁殖前沿。在这里，我们从理论上表明，这种趋化前线形态扰动的稳定性是由单个细胞的能力的限制，以感测，从而响应化学梯度。具体来说，细胞在一个突出的部分前暴露于一个较小的梯度，这减慢了他们，促进稳定，但他们也更强烈地响应梯度，这加快了他们，促进不稳定。我们预测，这种竞争导致趋化指当传感是有限的，在太低的化学浓度。根据这一发现和E.大肠杆菌的趋化性，我们认为细胞的感觉机制可能已经进化，以避免这些限制，并确保稳定的前端传播。最后，由于对任何刺激的感知在一般的生命和活性物质中必然受到限制，因此感知诱导稳定性的原理可能在其他类型的定向迁移中起作用，例如硬旋转、趋电性和趋光性。
In contexts ranging from embryonic development to bacterial ecology, cell populations migrate chemotactically along self-generated chemical gradients, often forming a propagating front. Here, we theoretically show that the stability of such chemotactic fronts to morphological perturbations is determined by limitations in the ability of individual cells to sense and thereby respond to the chemical gradient. Specifically, cells at bulging parts of a front are exposed to a smaller gradient, which slows them down and promotes stability, but they also respond more strongly to the gradient, which speeds them up and promotes instability. We predict that this competition leads to chemotactic fingering when sensing is limited at too low chemical concentrations. Guided by this finding and by experimental data on E. coli chemotaxis, we suggest that the cells' sensory machinery might have evolved to avoid these limitations and ensure stable front propagation. Finally, as sensing of any stimuli is necessarily limited in living and active matter in general, the principle of sensing-induced stability may operate in other types of directed migration such as durotaxis, electrotaxis, and phototaxis.