What are we measuring with GABA magnetic resonance spectroscopy?
What are we measuring with GABA magnetic resonance spectroscopy?
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DOI：
10.4161/cib.4.5.16213
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发表时间：
2011-09-01
影响因子：
--
通讯作者：
Johansen-Berg, Heidi
中科院分区：
文献类型：
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作者：
Stagg, Charlotte J;Bachtiar, Velicia;Johansen-Berg, Heidi
最近的一些论文1 -3已经证明了体内GABA浓度之间的关系，使用磁共振光谱（MRS）评估，和个人的任务表现，提供了一个独特的洞察生理和行为之间的关系。然而，解释的功能意义的MRS GABA措施是不简单的。在这里，我们讨论了一些悬而未决的问题，如何在皮层区域内的GABA的总浓度与阶段性和紧张性GABA活动的皮质体积内的研究。
A number of recent papers1-3 have demonstrated a relationship between in vivo concentration of GABA, as assessed using Magnetic Resonance Spectroscopy (MRS), and an individual's task performance, giving a unique insight into the relationship between physiology and behavior. However, interpretation of the functional significance of the MRS GABA measure is not straightforward. Here we discuss some of the outstanding questions as to how total concentration of GABA within a cortical region relates to phasic and tonic GABA activity within the cortical volume studied.