Perceived viral load, but not actual HIV-1-RNA load, is associated with sexual risk behaviour among HIV infected homosexual men
Perceived viral load, but not actual HIV-1-RNA load, is associated with sexual risk behaviour among HIV infected homosexual men
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DOI：
10.1097/00002030-200409240-00010
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发表时间：
2004-09-24
期刊：
影响因子：
3.8
通讯作者：
Dukers, NHTM
中科院分区：
文献类型：
--
作者：
Stolte, IG;de Wit, JBF;Dukers, NHTM
背景资料：在采用高效抗逆转录病毒疗法后，感染艾滋病毒的男同性恋者中危险性行为和性传播感染增加，这证实有必要开展创新的预防活动。本研究的重点是时间趋势的性风险行为和预测的无保护的肛交在HAART时代HIV感染的同性恋mes.Methods：在2000-2003年，57例HIV感染的同性恋男子（平均年龄45岁）进行了采访，在三个连续的数据波。Logistic回归，校正重复测量，被用来评估时间趋势在危险的性行为，和HAART相关的信念之间的关联，以及感知和实际的病毒载量水平和CD 4细胞计数和随后的危险性行为。结果：与临时伴侣发生危险性行为的比例从2000年的10.5%上升到2003年的27.8%稳定性伴HIV阴性或未知者为5.3%~ 10.7%（P = 0.6）。同性恋男子与他们的病毒载量的有利的看法，更有可能从事随后的危险性行为与稳定的合作伙伴的负面或未知的艾滋病毒状态比男子与他们的病毒载量的不利的看法，这种关联是独立的实际HIV-1-RNA载量和CD 4细胞counts.Conclusion：在这组HIV感染的同性恋男子的危险性行为增加。感知的病毒载量，而不是实际的载量，与随后与阴性或未知HIV状态的稳定伴侣发生危险性行为有关。护理人员不仅应与患者讨论其实际病毒载量和CD 4细胞计数，还应讨论其感知的病毒载量。(C)2004年利平科特威廉姆斯威尔金斯。
Background: Increases in sexual risk behaviour and sexually transmitted infections among HIV-infected homosexual men after the introduction of highly active antiretroviral therapy (HAART) confirm the need for innovative prevention activities. The present study focused on time trends in sexual risk behaviour and predictors for unprotected anal intercourse in the HAART era among HIV-infected homosexual men.Methods: In 2000-2003, 57 HIV-infected homosexual men (mean age 45 years) were interviewed in three serial data waves. Logistic regression, correcting for repeated measurements, was used to assess time trends in risky sex, and the association between HAART-related beliefs, and both the perceived and actual viral load level and CD4 cell counts and subsequent risky sex.Results: Risky sex with casual partners increased from 10.5% in 2000 to 27.8% in 2003 (P < 0.01), and with steady partners of negative or unknown HIV status from 5.3% to 10.7% (P = 0.6). Homosexual men with a favourable perception of their viral load were more likely to engage in subsequent risky sex with steady partners of negative or unknown HIV status than men with a less favourable perception of their viral load; this association was independent of the actual HIV-1-RNA load and CD4 cell counts.Conclusion: Risky sex increased in this group of HIV-infected homosexual men. The perceived viral load, but not the actual load, is associated with subsequent risky sex with steady partners of negative or unknown HIV status. Care givers should discuss with patients not only their actual viral load and CD4 cell count but also their perceived viral load. (C) 2004 Lippincott Williams Wilkins.