Repair, regenerative and supportive therapies of the annulus fibrosus: achievements and challenges.
Repair, regenerative and supportive therapies of the annulus fibrosus: achievements and challenges.
复制标题
DOI：
10.1007/s00586-008-0856-x
复制
发表时间：
2009-03
影响因子：
2.8
通讯作者：
Smit, Theodoor H.
中科院分区：
文献类型：
--
作者：
Bron, Johannes Leendert;Helder, Marco N.;Meisel, Hans-Jorg;Royen, Barend J. Van;Smit, Theodoor H.
腰椎间盘切除术是一种非常有效的神经减压治疗患者的坐骨神经痛由于髓核疝。然而，这些患者的高复发率和持续的术后腰痛需要引起严重关注。在过去的十年里，组织工程策略的发展主要针对椎间盘髓核（NP）的再生。处理受损纤维环的伴随技术现在越来越被认为是强制性的，以防止再次疝出，增加NP修复的潜力并限制NP替代疗法。在目前的审查中，在这个迅速崛起的研究领域的要求，成就和挑战进行了讨论。
Lumbar discectomy is a very effective therapy for neurological decompression in patients suffering from sciatica due to hernia nuclei pulposus. However, high recurrence rates and persisting post-operative low back pain in these patients require serious attention. In the past decade, tissue engineering strategies have been developed mainly targeted to the regeneration of the nucleus pulposus (NP) of the intervertebral disc. Accompanying techniques that deal with the damaged annulus fibrous are now increasingly recognised as mandatory in order to prevent re-herniation to increase the potential of NP repair and to confine NP replacement therapies. In the current review, the requirements, achievements and challenges in this quickly emerging field of research are discussed.
登录
查看更多内容
影响因子：
2.8
作者：
Alini, M;Roughley, PJ;Aebi, M
通讯作者：
Aebi, M
影响因子：
3
作者：
ADAMS, MA;HUTTON, WC
通讯作者：
HUTTON, WC
影响因子：
2.9
作者：
CASSIDY, JJ;HILTNER, A;BAER, E
通讯作者：
BAER, E
影响因子：
3
作者：
Atlas, SJ;Keller, RB;Singer, DE
通讯作者：
Singer, DE
影响因子：
5.3
作者：
Andersson, GBJ;An, HS;Setton, LA
通讯作者：
Setton, LA