The omega-3 index as a risk factor for coronary heart disease
The omega-3 index as a risk factor for coronary heart disease
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DOI：
10.1093/ajcn/87.6.1997s
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发表时间：
2008-06-01
影响因子：
7.1
通讯作者：
Harris, William S.
中科院分区：
文献类型：
--
作者：
Harris, William S.
由于n-3（或ω-3）脂肪酸（FA）（二十碳五烯酸和二十二碳六烯酸）的血液浓度是饮食摄入量的强烈反映，因此建议将n-3 FA生物标志物ω-3指数（红细胞二十碳五烯酸加二十二碳六烯酸）视为冠心病死亡率，特别是心源性猝死的潜在风险因素。omega-3指数满足了风险因素的许多要求，包括一致的流行病学证据，合理的作用机制，可重复的测定，与经典风险因素的独立性，可修改性，以及最重要的是，证明提高水平将降低心脏事件的风险。测量膜浓度的n-3脂肪酸是一个合理的方法，生物状态评估，因为这些脂肪酸似乎发挥其有益的代谢作用，因为他们的行动在膜。它们改变膜的物理特性和膜结合蛋白的活性，并且一旦被细胞内磷脂酶从膜储存释放，它们可以与离子通道相互作用，转化为多种生物活性类花生酸，并作为几种核转录因子的配体，从而改变基因表达。omega-3指数与其他心脏性猝死的风险因素相比非常有利。建议的omega-3指数风险区（红细胞脂肪酸百分比）：高风险，8%。在n-3 FA生物状态评估可用于患者的常规临床评价之前，必须提供标准化的实验室方法和质量控制材料。
Because blood concentrations of n-3 (or omega-3) fatty acids (FAs) (eicosapentaenoic and docosahexaenoic acids) are a strong reflection of dietary intake, it is proposed that a n-3 FA biomarker, the omega-3 index (erythrocyte eicosapentaenoic acid plus docosahexaenoic acid), be considered as a potential risk factor for coronary heart disease mortality, especially sudden cardiac death. The omega-3 index fulfills many of the requirements for a risk factor including consistent epidemiologic evidence, a plausible mechanism of action, a reproducible assay, independence from classic risk factors, modifiability, and, most important, the demonstration that raising levels will reduce risk for cardiac events. Measuring membrane concentrations of n-3 FAs is a rational approach to biostatus assessment as these FAs appear to exert their beneficial met abolic effects because of their actions in membranes. They alter membrane physical characteristics and the activity of membrane-bound proteins, and, once released by intracellular phospholipases from membrane stores, they can interact with ion channels, be converted into a wide variety of bioactive eicosanoids, and serve as ligands for several nuclear transcription factors, thereby altering gene expression. The omega-3 index compares very favorably with other risk factors for sudden cardiac death. Proposed omega-3 index risk zones are (in percentages of erythrocyte FAs): high risk, 8%. Before assessment of n-3 FA biostatus can be used in routine clinical evaluation of patients, standardized laboratory methods and quality control materials must become available.