Glutamate Promotes Contraction of the Rat Ductus Arteriosus
Glutamate Promotes Contraction of the Rat Ductus Arteriosus
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DOI：
10.1253/circj.cj-16-0649
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发表时间：
2016-11-01
影响因子：
3.3
通讯作者：
Ishikawa, Yoshihiro
中科院分区：
文献类型：
--
作者：
Fujita, Shujiro;Yokoyama, Utako;Ishikawa, Yoshihiro
背景：极早产儿常合并动脉导管未闭（PDA）。最近的建议包括立即开始在极早产儿中补充氨基酸。然而，氨基酸对动脉导管（DA）闭合的影响仍然未知。方法和结果：在人类新生儿在第2天的Aminogram结果显示，极早产儿血浆谷氨酸浓度显著降低（
Background: Extremely preterm infants frequently have patent ductus arteriosus (PDA). Recent recommendations include immediately beginning amino acid supplementation in extremely preterm infants. However, the effect of amino acids on closure of the ductus arteriosus (DA) remains unknown.Methods and Results: Aminogram results in human neonates at day 2 revealed that the plasma glutamate concentration was significantly lower in extremely preterm infants (