High-frequency electrical conduction block of mammalian peripheral motor nerve
High-frequency electrical conduction block of mammalian peripheral motor nerve
复制标题
DOI：
10.1002/mus.20428
复制
发表时间：
2005-12-01
期刊：
影响因子：
3.4
通讯作者：
Kilgore, KL
中科院分区：
文献类型：
--
作者：
Bhadra, N;Kilgore, KL
一种快速有效、快速逆转的周围神经动作电位阻断方法可用于肌肉痉挛和疼痛的治疗。高频交流(HFAC)正弦波形是提供这种类型的块的一种可能的手段。在活体哺乳动物模型中，HFAC被用来阻断周围运动神经活动。频率从10 kHz到30 kHz，幅度在2到10V之间。在所有频率下均可获得完全可逆的运动阻滞。阻断阈值幅度与频率呈线性关系，最低阈值为10 kHz。HFAC传导有三个阶段：起搏反应阶段、非同步放电阶段和完全或部分阻断的稳定状态。通过使用最佳的频率-幅度组合，可以最小化起始响应和异步触发。总体而言，30 kHz和10V组合的起搏反应最低。
A quick-acting, quick-reversing method for blocking action potentials in peripheral nerves could be used in the treatment of muscle spasticity and pain. A high-frequency alternating-current (HFAC) sinusoidal,waveform is one possible means for providing this type of block. HFAC was used to block peripheral motor nerve activity in an in vivo mammalian model. Frequencies from 10 to 30 kHz at amplitudes of between 2 and 10 V were investigated. A complete and reversible motor block was obtained at all frequencies. The block threshold amplitudes showed a linear relationship with frequency, the lowest threshold being at 10 kHz. HFAC block has three phases: an onset response; a period of asynchronous firing; and a steady state of complete or partial block. The onset response and the asynchronous firing can be minimized by using an optimal frequency-amplitude combination. In general, the onset response was lowest for the combination of 30 kHz and 10 V.