Genetic correlation of fatty acid composition with growth, carcass, fat deposition and meat quality traits based on GWAS data in six pig populations
Genetic correlation of fatty acid composition with growth, carcass, fat deposition and meat quality traits based on GWAS data in six pig populations
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基于 6 个猪群 GWAS 数据的脂肪酸组成与生长、胴体、脂肪沉积和肉质性状的遗传相关性
DOI：
10.1016/j.meatsci.2018.12.008
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发表时间：
2019-04-01
期刊：
影响因子：
7.1
通讯作者：
Yang, Bin
中科院分区：
文献类型：
--
作者：
Zhang, Yifeng;Zhang, Junjie;Yang, Bin
本研究采用全基因组SNP技术，对6个猪群体2448头猪的背最长肌脂肪酸组成与生长、胴体、脂肪沉积和肉质等32个性状的遗传相关性进行了研究。在GWAS中发现的大多数饱和脂肪酸（C14：0、C16：0和C18：0）和单饱和脂肪酸（C18：1n9和C16：1n7）的显著位点，包括在GWAS中的C14：0、C16：0和C18：0基因附近的位点，对所有32个性状的影响都可以忽略或很弱。脂肪沉积性状与脂肪酸组成的遗传相关性最高。背膘厚和肌内脂肪含量与C18：2n6的遗传相关性较强，与C18：1n9的遗传相关性较强。肌内脂肪含量与饱和脂肪酸（SFA）在6个群体中一致呈正相关。本研究揭示了猪脂肪酸组成与其他经济性状的共同遗传控制，为猪脂肪酸组成遗传改良育种策略的设计提供了理论依据。
This study investigated genetic correlations of longissimus muscle fatty acid composition with 32 traits related to growth, carcass, fat deposition and meat quality in 2448 pigs from six populations using genome wide SNP data. Most of significant loci for saturated (C14:0, C16:0 and C18:0) and mono-saturated fatty acids (C18:1n9 and C16:1n7) identified in GWAS, including those near ELOVL6, SCD and FASN genes, displayed negligible or weak effects on all the 32 traits. Fat deposition traits were the most relevant traits for fatty acid composition in genetic correlations. Backfat thickness and intramuscular fat content consistently showed strong negative genetic correlations with C18:2n6, and positive genetic correlations with C18:1n9 at least five populations. Intramuscular fat content consistently has positive correlations with saturated fatty acids (SFA) in six populations. This study provided insights into shared genetic control of fatty acid composition and the other economic traits, which is helpful in design of breeding strategies to genetically improve fatty acid composition in pork.